2. GPCR/G Protein Cytoskeleton Cell Cycle/DNA Damage
  3. LPL Receptor PAK
  4. Fingolimod-d4

Fingolimod-d4  (Synonyms: FTY720 free based-d4)

Cat. No.: HY-11063S Purity: 98.97%
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Fingolimod-d4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

For research use only. We do not sell to patients.

Fingolimod-d<sub>4</sub> Chemical Structure

Fingolimod-d4 Chemical Structure

CAS No. : 1346747-38-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Fingolimod-d4:

Fingolimod-d4 Related Antibodies

Top Publications Citing Use of Products

View All LPL Receptor Isoform Specific Products:

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

View All PAK Isoform Specific Products:

View All Isoforms
PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fingolimod-d4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fingolimod-d4 Related Antibodies
Molecular Weight

311.50

Formula

C19H29D4NO2
CAS No.
Unlabeled CAS

162359-55-9
Appearance

Solid

Color

White to off-white

SMILES

OC([2H])([2H])C(CCC1=CC=C(CCCCCCCC)C=C1)(N)C([2H])([2H])O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMF : ≥ 20 mg/mL (64.21 mM)

DMF : ≥ 20 mg/mL (64.21 mM)

DMSO : ≥ 10 mg/mL (32.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 10 mg/mL (32.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 5 mg/mL (16.05 mM)

Ethanol : ≥ 5 mg/mL (16.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2103 mL 16.0514 mL 32.1027 mL
5 mM 0.6421 mL 3.2103 mL 6.4205 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / Ethanol / DMSO / DMSO / DMF / DMF 1 mM 3.2103 mL 16.0514 mL 32.1027 mL 80.2568 mL
5 mM 0.6421 mL 3.2103 mL 6.4205 mL 16.0514 mL
10 mM 0.3210 mL 1.6051 mL 3.2103 mL 8.0257 mL
15 mM 0.2140 mL 1.0701 mL 2.1402 mL 5.3505 mL
DMSO / DMSO / DMF / DMF 20 mM 0.1605 mL 0.8026 mL 1.6051 mL 4.0128 mL
25 mM 0.1284 mL 0.6421 mL 1.2841 mL 3.2103 mL
30 mM 0.1070 mL 0.5350 mL 1.0701 mL 2.6752 mL
DMF / DMF 40 mM 0.0803 mL 0.4013 mL 0.8026 mL 2.0064 mL
50 mM 0.0642 mL 0.3210 mL 0.6421 mL 1.6051 mL
60 mM 0.0535 mL 0.2675 mL 0.5350 mL 1.3376 mL
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Fingolimod-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fingolimod-d41346747-38-3FTY720 free based-d4LPL ReceptorPAKLysophospholipid Receptorp21 activated kinasesInhibitorinhibitorinhibit

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