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FoxO3a

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By Targets:	Akt (3) Apoptosis (4) Autophagy (2) EGFR (2) FOXO (1) Organoid (2) Phosphatase (1) Phosphodiesterase (PDE) (2) PI3K (1) Sirtuin (1) Tau Protein (1)
By Research Areas:	Cancer (8) Metabolic Disease (1) Neurological Disease (2)

10

Inhibitors & Agonists

2

Natural
Products

1

Recombinant Proteins

3

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Ipatasertib Maximum Cited Publications 45 Publications Verification GDC-0068; RG7440	Organoid Akt Apoptosis	Cancer
Ipatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for *Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a and NF-κB through inhibition of Akt* leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models .

Butein 4 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a ^[3]. Butein is a SIRT1 activator (STAC).

PhosTAC5	Others	Cancer
PhosTAC5 is a phosphorylation targeting chimera (PhosTAC) molecule composed of a linker with fivePEG groups. PhosTAC5 induces dephosphorylation of PDCD4 and FOXO3a .

PhosTAC3	Others	Cancer
PhosTAC3 is a phosphorylation targeting chimera (PhosTAC) molecule composed of a linker with three PEG groups. PhosTAC3 induces dephosphorylation of PDCD4 and FOXO3a .

JY-2 1 Publications Verification	FOXO	Metabolic Disease
JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC₅₀ of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity .

PhosTAC7 2 Publications Verification	Phosphatase Tau Protein	Neurological Disease Cancer
PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, *FOXO3a* protein, and Tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases .

Ipatasertib tosylate GDC-0068 tosylate; RG7440 tosylate	Organoid Akt Apoptosis	Cancer
Ipatasertib (GDC-0068) tosylate is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for *Akt1/2/3, respectively. Ipatasertib tosylate synchronously activates FoxO3a and NF-κB through inhibition of Akt* leading to p53-independent activation of PUMA. Ipatasertib tosylate also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models .

Butein (Standard)	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a ^[3]. Butein is a SIRT1 activator (STAC).

8AQ−Cu−5Iu	Sirtuin	Neurological Disease
8AQ?Cu?5Iu is an activator of SIRT1. 8AQ?Cu?5Iu exhibits neuroprotective effects by modulating the *SIRT1/3-FOXO3a* signaling pathway. 8AQ?Cu?5Iu can used in study attenuating neurodegenerative diseases .

RLX PD 139530	PI3K Akt	Cancer
RLX (PD 139530) is a PI3K/Akt/FoxO3a signaling inhibitor, possessing significant therapeutic potential in experimental colon cancer. RLX can effectively modulate the tumor microenvironment, enhancing the efficacy of cancer immunotherapy. RLX demonstrates the ability to improve the retention time of therapeutic agents within the tumor microenvironment by utilizing advanced nanoparticle delivery systems. RLX can be integrated with various treatment modalities, such as chemotherapy and radiotherapy, to enhance overall tumor therapy effectiveness. RLX highlights the necessity for further research into the tumor microenvironment’s dynamics to develop more tailored treatment approaches for diverse tumor types.

Cat. No.	Compare	Product Name	Species	Source

	FOXO3 Protein, Human (HEK293, His) AF6q21; FKHRL1; FKHRL1P2; FoxO2; FoxO3a	Human	HEK293
	The FOXO3 protein is a multifaceted transcriptional activator that regulates apoptosis, autophagy, and post-transcriptional MYC control. It actively regulates autophagy in skeletal muscle and induces autophagy gene expression under starvation conditions. FOXO3 Protein, Human (HEK293, His) is the recombinant human-derived FOXO3 protein, expressed by HEK293 , with C-10*His labeled tag.

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	FOXO3 Antibody FoxO3; FKHRL1; FoxO3a; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB	Human
	FOXO3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 71 kDa, targeting to FOXO3. It can be used for WB assays with tag free, in the background of Human.

	*Phospho-FOXO3A (Ser253) Antibody* FoxO3; FKHRL1; FoxO3a; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB	Human, Mouse, Rat
	Phospho-FOXO3A (Ser253) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 71 kDa, targeting to Phospho-FOXO3A (Ser253). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

	*Phospho-FOXO3a(Ser253) Antibody*	WB, IHC-P	Human, Mouse, Rat
	Phospho-FOXO3a(Ser253) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 71 kDa, targeting to Phospho-FOXO3a(S253). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

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