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Isoforms Recommended: FOXO1
Results for "

Foxo1

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

6

Natural
Products

3

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153617
    FOXO1-IN-3

    		FOXO Metabolic Disease
    FOXO1-IN-3 is a highly-selective and orally active FOXO1 inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain [1].
    FOXO1-IN-3
  • HY-100596
    AS1842856
    Maximum Cited Publications
    59 Publications Verification

    		 Autophagy Metabolic Disease
    AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy [1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1 .
    AS1842856
  • HY-111299
    Psammaplysene A

    		Apoptosis Cancer
    Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of FOXO1, leading to cell cycle arrest and apoptosis, and can be used in cancer research [1].
    Psammaplysene A
  • HY-153347
    JY-2
    1 Publications Verification

    		 FOXO Metabolic Disease
    JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC50 of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity [1].
    JY-2
  • HY-123046
    AS1708727
    3 Publications Verification

    		 Autophagy Metabolic Disease Cancer
    AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively [1].
    AS1708727
  • HY-139348
    PFI-90

    		Histone Demethylase Apoptosis Cancer
    PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).
    PFI-90
  • HY-RS05069
    FOXO1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FOXO1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FOXO1 Human Pre-designed siRNA Set A
    FOXO1 Human Pre-designed siRNA Set A
  • HY-169417
    Euphjatrophane M

    		FOXO NF-κB Interleukin Related TNF Receptor Inflammation/Immunology
    Euphjatrophane M (Compound 6) is a FOXO1 inhibitor that can reduce the phosphorylation of NF-κB p65 and has anti-inflammatory properties. Euphjatrophane M can inhibit the production of nitric oxide and also suppress the mRNA expression of IL-6, IL-1β, and TNFα in RAW 264.7 macrophages induced by lipopolysaccharide (LPS, HY-D1056) [1].
    Euphjatrophane M
  • HY-N3542
    Carpachromene

    		Glycosidase Cancer
    Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway [1].
    Carpachromene
  • HY-122959
    Kihadanin B

    		Akt PPAR Metabolic Disease
    Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes [1].
    Kihadanin B
  • HY-N7676
    Marein
    1 Publications Verification

    		 AMPK HDAC Cardiovascular Disease Neurological Disease Metabolic Disease
    Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects [1] .
    Marein
  • HY-P4790
    Acetyl-Exenatide

    		PI3K Akt Metabolic Disease
    Acetyl-Exenatideyes is an acetylated derivative of Exenatide. Exenatide has the function similar to insulin, which can be used for research of type 2 diabetes. Exenatide can promote Th17 differentiation, inhibits Tregs differentiation, downregulates PI3K/Akt/FoxO1 phosphorylation [1].
    Acetyl-Exenatide
  • HY-15145A
    SRT 1720 dihydrochloride
    35+ Cited Publications

    		 Sirtuin Autophagy Metabolic Disease
    SRT 1720 dihydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 [1].
    SRT 1720 dihydrochloride
  • HY-149216
    Anticancer agent 103

    		Others Cancer
    Anticancer agent 103 (Compound 2k) is a potent anticancer agent [1].
    Anticancer agent 103
  • HY-P99422
    Adebrelimab

    SHR-1316

    		 PD-1/PD-L1 Apoptosis Cancer
    Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal PD-L1 (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC) [1] .
    Adebrelimab
  • HY-N0748
    Oxypaeoniflorin
    3 Publications Verification

    		 Others Neurological Disease Inflammation/Immunology
    Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects [1] .
    Oxypaeoniflorin
  • HY-N0748R
    Oxypaeoniflorin (Standard)

    		Others Neurological Disease Inflammation/Immunology
    Oxypaeoniflorin (Standard) is the analytical standard of Oxypaeoniflorin. This product is intended for research and analytical applications. Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects [1] .
    Oxypaeoniflorin (Standard)
  • HY-111380
    EHT 1610
    1 Publications Verification

    		 DYRK Neurological Disease
    EHT 1610 is a potent inhibitor of DYRK, with IC50s of 0.36 nM (DYRK1A), 0.59 nM (DYRK1B), respectively. EHT 1610 exhibits antileukemia effect, regulates cell cycle and induces cell apoptosis [1] - .
    EHT 1610

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