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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

GFRAL Antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TGF-beta/Smad (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1)

1

Inhibitors & Agonists

2

Inhibitory Antibodies

Targets Recommended: ADC Antibody Antibody-Drug Conjugates (ADCs) ADC Linker PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Ponsegromab 1 Publications Verification PF 06946860	TGF-beta/Smad	Cancer
Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 monoclonal antibody with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to *GFRAL, thereby blocking GDF15/GFRAL*-mediated signaling. Ponsegromab can be used in the research of cancers .

Cat. No.	Product Name	Target	Research Area

Ponsegromab 1 Publications Verification PF 06946860	TGF-beta/Smad	Cancer
Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 monoclonal antibody with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to *GFRAL, thereby blocking GDF15/GFRAL*-mediated signaling. Ponsegromab can be used in the research of cancers .

NGM-120	Inhibitory Antibodies	Inflammation/Immunology
NGM-120 is a CHO-expressed human antibody that targets *GFRAL*. NGM-120 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.7 kDa. The isotype control for NGM-120 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

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