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Results for "

Guggulsterone

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

5

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107738
    Guggulsterone
    10+ Cited Publications

    Z/E-Guggulsterone

    		 Apoptosis JNK Akt Caspase FXR Autophagy Cancer
    Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively .
    Guggulsterone
  • HY-N7781
    (-)-(E)-Guggulsterone

    (E)-Guggulsterone

    		 Drug Metabolite Metabolic Disease
    (-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity .
    (-)-(E)-Guggulsterone
  • HY-110066
    (Z)-Guggulsterone
    3 Publications Verification

    		 Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR Cardiovascular Disease Cancer
    (Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection .
    (Z)-Guggulsterone
  • HY-N7781R
    (-)-(E)-Guggulsterone (Standard)

    (E)-Guggulsterone (Standard)

    		 Drug Metabolite Metabolic Disease
    (-)-(E)-Guggulsterone (Standard) is the analytical standard of (-)-(E)-Guggulsterone. This product is intended for research and analytical applications. (-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity .
    (-)-(E)-Guggulsterone (Standard)
  • HY-110066R
    (Z)-Guggulsterone (Standard)

    		Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR Cancer
    (Z)-Guggulsterone (Standard) is the analytical standard of (Z)-Guggulsterone. This product is intended for research and analytical applications. (Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection .
    (Z)-Guggulsterone (Standard)

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