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HCoV229E

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (2) Arenavirus (1) Calcium Channel (1) DNA Methyltransferase (1) DNA/RNA Synthesis (1) HIV (1) PI3K (1) PROTACs (2) RSV (1) SARS-CoV (17) Sodium Channel (1) Virus Protease (3)
By Research Areas:	Cancer (3) Infection (17)

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Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132169

HCoV-229E-IN-1	SARS-CoV	Infection
HCoV-229E-IN-1 is a potent inhibitor of *HCoV-229E* replication, with an EC₅₀ of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively .

HY-13433

Thapsigargin Maximum Cited Publications 81 Publications Verification	Calcium Channel SARS-CoV Apoptosis	Infection Cancer
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-136149

Mpro inhibitor N3	SARS-CoV Virus Protease	Infection
Mpro inhibitor N3 is a potent SARS-CoV-2 MPro inhibitor with an EC₅₀ value of 16.77 µM. Mpro inhibitor N3 shows antiviral activities against HCoV-229E, FIPV, IBV and MHV-A59 .

HY-12473

Vps34-IN-2 2 Publications Verification	PI3K SARS-CoV	Cancer
Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC₅₀s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively . Vps34-IN-2 shows antiviral activity against SARS-CoV-2 (IC₅₀ of 3.1 μM), *HCoV-229E* (IC₅₀ of 0.7 μM) and *HCoV-OC43* .

HY-136149A

Mpro inhibitor N3 hemihydrate	SARS-CoV Virus Protease	Infection
Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC₅₀ of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC₅₀ of 4.0 μM, 8.8 μM, and 2.7 μM, respectively .

HY-168889

*HRSV/hCoV-229E-IN-1*	RSV SARS-CoV	Infection
HRSV/hCoV-229E-IN-1 (compound 8X) is a potent HRSV and *hCoV-229E* inhibitor with an IC₅₀ value of 2.1 µM for hCoV-229E. HRSV/hCoV-229E-IN-1 inhibits cell viability .

HY-168557

SARS-CoV-2-IN-101	SARS-CoV	Infection
SARS-CoV-2-IN-101 (compound 10O) is a potent and orally active SARS-CoV-2 inhibitor with an EC₅₀ value of 0.64 µM for HCoV-229E. SARS-CoV-2-IN-101 shows cyotoxicity. SARS-CoV-2-IN-101 decreases the expression of HCoV-229E N protein and RNA level. SARS-CoV-2-IN-101 shows broad-spectrum anti-coronaviral effect .

HY-155097

SARS-CoV-2-IN-53	SARS-CoV	Infection
ARS-CoV-2-IN-53 (Compd 5d) can inhibit the replication of SARS-CoV-2 with an EC₅₀ value of 14.3 μM. ARS-CoV-2-IN-5 shows significant antiviral activity against human coronavirus 229E (HCoV-229E) .

HY-133828

Cinanserin	5-HT Receptor SARS-CoV	Infection
Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with K_i values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CL ^pro inhibitor with an K_D value of 49.4, 18.2 µM for SARS-CoV 3CL ^pro, HCoV-229E 3CL ^pro, respectively. Cinanserin reduces systemic burn edema levels .

HY-173081

4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin	SARS-CoV	Infection
4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin (Compound 2d) is a broad-spectrum anti-coronaviral agent via targeting frameshifting element (FSE). 4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin inhibits HCoV-OC43 and HCoV-229E with EC₅₀ values of 0.85 μM and 1.45 μM. 4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin shows a dual-target mechanism that acts on both viral FSE RNA and host DIS3L2 .

HY-161356

BPR3P0128	SARS-CoV	Infection
BPR3P0128 is an orally active, non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor that has been shown to inhibit the activity of various SARS-CoV-2 variants. The EC₅₀ for SARS-CoV-2 and HCoV-229E are 0.62 µM and 0.14 µM. BPR3P0128 demonstrates effective anti-pancoronavirus activity within the submicromolar range. PR3P0128 shows synergistic antiviral activity when combined with Remdesivir (HY-104077) .

HY-128067

5-(N,N-Hexamethylene)-amiloride 2 Publications Verification Hexamethylene amiloride; HMA	Sodium Channel HIV Apoptosis	Infection Cancer
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na ⁺/H ⁺ exchanger inhibitor, which decreases the intracellular pH (pH_i) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC₅₀s of 3.91 μM and 1.34 μM, respectively .

HY-161789

PROTAC SARS-CoV-2 Mpro degrader-3	PROTACs SARS-CoV Virus Protease	Infection
PROTAC SARS-CoV-2 Mpro degrader-3 (Compound P2) exhibits antiviral activity through the degradation of the main protease (Mpro) of human coronaviruses (HCoVs) (DC₅₀=27 μM). PROTAC SARS-CoV-2 Mpro degrader-3 inhibits the viral replication, with EC₅₀ of 4.6 μM, 4.6 μM, and 0.71 μM, for human coronaviruses HCoV-229E, HCoV-OC43 and SARS-CoV-2, respectively. (Pink: ligand for target protein Mpro ligand 2 (HY-161791); Black: linker (HY-161792); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) .

HY-157805

PROTAC SARS-CoV-2 Mpro degrader-2	PROTACs SARS-CoV	Infection
PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 M ^pro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC₅₀ = 10.8 μM), HCoV-OC43 (EC₅₀ = 1.6 μM) and HCoV-229E (EC₅₀ = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC₅₀ of 0.89 μM .

HY-163913

SARS-CoV-IN-5	SARS-CoV	Infection
SARS-CoV-IN-5 (compound 49) is a highly selective, nonpeptidic and noncovalent 3CL ^pro inhibitor with IC₅₀s of 38 nM, 21.1 nM and 86 nM for 3CL ^pro of SARS-CoV-1, SARS-CoV-2, Bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 delta variant with an EC₅₀ of 0.272 μM. SARS-CoV-IN-5 significantly reduces the lung viral copies in a K18-hACE2 transgenic mouse model. SARS-CoV-IN-5 has good target-specific and potential broad-spectrum anticoronavirus activities against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9 .

HY-170799

HNC-1664	DNA/RNA Synthesis SARS-CoV Arenavirus	Infection
HNC-1664 is the orally active inhibitor for RNA-dependent RNA polymerase (RdRP). HNC-1664 exhibits broad-spectrum antiviral activity against coronavirus (SARS-CoV-2 wildtype and its mutants XBB.1.18, HK.3.1, BF.7.14, BA.1HCoV-229E, HCoV-OC43) and arenavirus. HNC-1664 exhibits anti-infectious activity in SARS-CoV-2 Delta infected mouse models .

HY-159890

MTI013	SARS-CoV	Infection
MTI013 is a selective SARS-CoV-2 nsp14 Mtase inhibitor (IC₅₀: 2.98 μM) and an antiviral agent (IC₅₀: 10.33 μM in HCoV-229E-infected Huh7 cells). MTI013 also shows a synergistic antiviral effect with the RdRp inhibitor SHEN26 (HY-155488) .

HY-170524

TDI-015051	SARS-CoV DNA Methyltransferase	Infection
TDI-015051 is an orally active inhibitor for SARS-CoV-2 nonstructural protein 14 (NSP14) with an IC₅₀ ≤0.15 nM. TDI-015051 inhibits SARS-CoV-2 NSP14 in Huh-7.5 cell (EC₅₀=11.4 nM) and in ACE2-TMPRSS2 expressing A549 cell (EC₅₀=64.7 nM). TDI-015051 also inhibits other coronaviruses like α-hCoV-NL63, α-hCoV-229E and β-hCoV-MERS with IC₅₀s of 1.7, 2.6 and 3.6 nM, respectively. TDI-015051 binds to the SAH-stabilized cap binding pocket, inhibits viral RNA methylation and viral replication, and exhibits anti-infectious activity in mouse models .

Thapsigargin 80+ Cited Publications	Infection Classification of Application Fields Terpenoids Source classification Diterpenoids Umbelliferae Plants Disease Research Fields Thapsia garganica L. Cancer	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

Species:	Virus (3)
Tag:	His (3)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P76976

	HCoV-229E Nucleoprotein/NP Protein (NP_073556, His) Human coronavirus (HCoV-229E) Nucleoprotein / NP Protein (His)	Virus	E. coli
	H-CoV Nucleoprotein (NP, N) is a homodimer with nonspecific binding activity toward nucleic acids. NP packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly, enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication through its interactions with the viral genome and membrane protein M. HCoV-229E Nucleoprotein/NP Protein (NP_073556, His) is the recombinant Virus-derived HCoV-229E Nucleoprotein/NP protein, expressed by E. coli , with N-His labeled tag.

HY-P76384

	HCoV-229E Spike/S Protein (APT69883, sf9, His) Human coronAvirus (HCoV-229E) Spike Protein (S1+S2 ECD, His)	Virus	Sf9 insect cells
	Coronaviruses (CoVs) are enveloped, positive-sense, single-stranded RNA viruses with the largest genomes known among RNA viruses. The CoVs S-protein mediates receptor binding and fusion of the viral and host cell membranes. HCoV-229E is an alpha-coronaviruse that uses different host proteins as receptors.In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation. HCoV-229E exploits trypsin, cathepsin L and TMPRSS2 to complete the fusion activation mediated by the S protein. HCoV-229E Spike/S Protein (APT69883, sf9, His) is the recombinant Virus-derived HCoV-229E Spike/S protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P76385

	HCoV-229E Spike/S1 Protein (APT69883, HEK293, His) Human coronAvirus (HCoV-229E) Spike/S1 Protein (S1 Subunit, His)	Virus	HEK293
	Coronaviruses (CoVs) are enveloped, positive-sense, single-stranded RNA viruses with the largest genomes known among RNA viruses. The CoVs S-protein mediates receptor binding and fusion of the viral and host cell membranes. HCoV-229E is an alpha-coronaviruse that uses different host proteins as receptors.In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation. HCoV-229E exploits trypsin, cathepsin L and TMPRSS2 to complete the fusion activation mediated by the S protein. HCoV-229E Spike/S1 Protein (APT69883, HEK293, His) is the recombinant Virus-derived HCoV-229E Spike/S1 protein, expressed by HEK293 , with C-His labeled tag. The total length of HCoV-229E Spike/S1 Protein (APT69883, HEK293, His) is 521 a.a., with molecular weight of ~58.3 KDa.

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HCoV229E

Inhibitors & Agonists

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