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HDAC6-IN-4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) E3 Ligase Ligand-Linker Conjugates (1) HDAC (4) Ligands for Target Protein for PROTAC (1) PROTACs (2)
By Research Areas:	Cancer (5) Inflammation/Immunology (1)
Click Chemistry:	Azide (1) Alkynes (1)

5

Inhibitors & Agonists

2

Click Chemistry

Targets Recommended: Dan family AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*HDAC6-IN-4*	HDAC Apoptosis	Inflammation/Immunology Cancer
HDAC6-IN-4 (C10) is a potent, orally active and highly selective *HDAC6* inhibitor with an IC₅₀ value of 23 nM. HDAC6-IN-4 induces cancer cells apoptosis and shows significant antitumor efficacy, without obvious toxicity .

*HDAC6 degrader-4*	HDAC PROTACs	Cancer
HDAC6 degrader-4 is a PROTAC and a selective *HDAC6* degrader consists of a non-selective HDAC inhibitor and thalidomide-type E3 ligase ligand. HDAC6 degrader-4 can be used for cancer research .

HDAC6 ligand-3	HDAC Ligands for Target Protein for PROTAC	Cancer
HDAC6 ligand-3 is a ligand for *HDAC6* that can be used as target protein ligand for synthesis of PROTAC HDAC6 degrader 4 (HY-172359) .

Thalidomide-F-NH-C6-adize	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-F-NH-C6-adize is the conjugate of an E3 ligase (Cereblon) ligand and a linker, and can be used for synthesis of PROTAC HDAC6 degrader 4 (HY-172359) .

PROTAC HDAC6 degrader 4	PROTACs HDAC	Cancer
PROTAC HDAC6 degrader 4 (Compound 17c) is the PROTAC degrader for *HDAC6* with a DC₅₀ of 14 nM. PROTAC HDAC6 degrader 4 exhibits inhibitory activit against *HDAC1, HDAC2, HDAC3* and *HDAC6* with IC₅₀s of 2.2, 2.37, 0.61 and 0.295 μM, respectively . (Pink: ligand for target protein HDAC6 ligand-3 (HY-172360); Black: linker (HY-138387); Blue: ligand for cereblon E3 ligase (HY-W093272))

Cat. No.	Product Name		Classification

HDAC6 ligand-3		Alkynes
HDAC6 ligand-3 is a ligand for *HDAC6* that can be used as target protein ligand for synthesis of PROTAC HDAC6 degrader 4 (HY-172359) .

Thalidomide-F-NH-C6-adize		Azide
Thalidomide-F-NH-C6-adize is the conjugate of an E3 ligase (Cereblon) ligand and a linker, and can be used for synthesis of PROTAC HDAC6 degrader 4 (HY-172359) .

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