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HIV-1 protease-IN-11

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155690
    HIV-1 protease-IN-11

    		HIV Protease Infection
    HIV-1 protease-IN-11 (compound 34a) is a HIV-1 protease inhibitor with an IC50 of 0.41 nM. HIV-1 protease-IN-11 also exhibits significant activity against drug-resistant variant [1].
    HIV-1 protease-IN-11
  • HY-120812
    HIV-IN-11

    		HIV Protease Infection
    HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor [1].
    HIV-IN-11

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