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Results for "

Hyt

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-141676
    HyT36

    		EGFR Others
    HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3 .
    HyT36
  • HY-133129
    MS1943
    1 Publications Verification

    		 PROTACs Histone Methyltransferase Apoptosis Cancer
    MS1943 is an orally active, PROTAC-based, selective degrader of EZH2 that effectively reduces EZH2 levels in cells. MS1943 has anticancer activity and exhibits cytotoxic effects in a variety of TNBC cells while sparing normal cells. In addition, MS1943 maintains high potency (IC50=120 nM) in inhibiting EZH2 methyltransferase activity and is highly selective for EZH2. (Structure Note: RED, EZH2 ligand (HY-148458); Blue, Hyt (HY-W001578)) .
    MS1943
  • HY-153887
    HyT36(-Cl)

    		Others Others
    HyT36(-Cl) is the inactive control compound of HyT36, a small molecule hydrophobic tag compound that can be used in protein folding research .
    HyT36(-Cl)
  • HY-170376
    2-(2-Aminoethoxy)ethyl 2-(adamantan-1-yl)acetate

    		E3 Ligase Ligand-Linker Conjugates Others
    2-(2-Aminoethoxy)ethyl 2-(adamantan-1-yl) acetate is a conjugate of an Hyt hydrophobic group and a linker, which can be used in the synthesis of SARD279 (HY-164807) .
    2-(2-Aminoethoxy)ethyl 2-(adamantan-1-yl)acetate
  • HY-168682
    Adamantane-Butyl alcohol

    		Target Protein Ligand-Linker Conjugates Cancer
    Adamantane-Butyl alcohol is a selective and persistent degrader targeting the CDK8-cyclin C complex. Adamantane-Butyl alcohol is the linker for LL-K8-22 (PROTAC CDK8-cyclin C, HY-149209) and HyT .
    Adamantane-Butyl alcohol
  • HY-W037848
    Adamantan-1-ylmethanamine

    1-Aminomethyladamantane

    		 Others Cancer
    Adamantan-1-ylmethanamine (1-Aminomethyladamantane) is a Hyt hydrophobic group. Adamantan-1-ylmethanamine can be used in the synthesis of ZX782 (HY-161972) .
    Adamantan-1-ylmethanamine
  • HY-161974
    Adamantan-C-amide-PEG2-C-Br

    		Others Cancer
    Adamantan-C-amide-PEG2-C-Br is a conjugate of a Hyt hydrophobic group and a linker. Adamantan-C-amide-PEG2-C-Br can be used to synthesize ZX782 (HY-161972) .
    Adamantan-C-amide-PEG2-C-Br
  • HY-164807
    SARD279

    		PROTACs Androgen Receptor Cancer
    SARD279 is a potent and selective Androgen Receptor degrader with DC50 value of 1099 nM. SARD279 can be used in prostate cancer research .(Structure Note: Pink: target protein ligand (HY-117486); Blue,: Hyt (HY-W001578); Black: linker (HY-W004896))
    SARD279
  • HY-161972
    ZX782

    		PROTACs Glutathione Peroxidase Ferroptosis Cancer
    ZX782 is a Hty-type PROTAC targeting GPX4 and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol (HBA) and appears bright blue under acidic conditions, which can be used for quantitative determination . ZX782 is composed of target protein ligand (red part) ML-210 (HY-100003), PROTAC linker (black part) Bromo-PEG2-CH2-Boc (HY-141371) and Hty molecule (blue part) Adamantan-1-ylmethanamine (HY-W037848). The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br (HY-161974), and the activity control of the target protein ligand is Hydroxyl-ML-210 (HY-161973).
    ZX782

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