IL12p40

By Targets:	Epigenetic Reader Domain (1) IFNAR (1) Interleukin Related (2) Toll-like Receptor (TLR) (4)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (5)
Oligonucleotides:	CpG ODNs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2495

Isomucronulatol	Others	Inflammation/Immunology
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N6250

Isomucronulatol 7-O-glucoside Isomucronulatol 7-O-β-glucoside	Others	Inflammation/Immunology
Isomucronulatol 7-O-glucoside is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol 7-O-glucoside exhibits weak inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-150741C

ODN 2216 sodium 1 Publications Verification	Toll-like Receptor (TLR)	Cancer
ODN 2216 sodium is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 sodium induces high amounts of IFN-α and IFN-β. ODN 2216 sodium induces IFN-α by pDC (plasmacytoid DC) and *IL-12 (p40)* production by DC (dendritic cells). ODN 2216 sodium stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 sodium can activate NK cells and promote IFN-γ production of TCR-triggered CD4 ⁺ T cells .

HY-147375

Bromodomain inhibitor-10	Epigenetic Reader Domain	Cancer
Bromodomain inhibitor-10 (compound 128) is a potent bromodomain inhibitor with K_ds of 15.0, 2500 nM for BRD4-1 and BRD4-2, respectively. Bromodomain inhibitor-10 inhibits the production of IL12p40 .

HY-153900

TLR8 agonist 6	Toll-like Receptor (TLR)	Cancer
TLR8 agonist 6 (Compound A) is a TLR8 agonist, with an EC₅₀ of 0.052 μM. TLR8 agonist 6 induces IL-12p40 production in human PBMC (EC₅₀: 0.031 μM). TLR8 agonist 6 can be used in the research of virus resistance, infection resistance, autoimmunity, tumor, etc .

HY-N4061

Hedycoronen A	Interleukin Related	Inflammation/Immunology
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

HY-160231

ssRNA42 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
ssRNA42 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA42 (sodium) derives from ssRNA40 by replacement of all G nucleotides with adenosine. ssRNA42 activated human PBMCs to secrete IFN-α, TNF-a, IL- 12p40, and IL-6, but ssRNA42 failed to stimulated murine pDCs and PBMCs.

HY-150741

ODN 2216	Toll-like Receptor (TLR) IFNAR Interleukin Related	Infection Inflammation/Immunology Cancer
ODN 2216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and *IL-12 (p40)* production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4 ⁺ T cells .

Cat. No.	Product Name	Target	Research Area

HY-P990225

*Anti-Mouse IL-12 p40* Antibody (C17.8)**	Inhibitory Antibodies	Others
Anti-Mouse IL-12 p40 Antibody (C17.8) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse IL-12 p40.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2495

Isomucronulatol	Structural Classification Classification of Application Fields Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Flavonoids other families Leguminosae Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Others
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N6250

Isomucronulatol 7-O-glucoside Isomucronulatol 7-O-β-glucoside	Flavonoids Monophenols other families Classification of Application Fields Leguminosae Isoflavanones Source classification Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Inflammation/Immunology	Others
Isomucronulatol 7-O-glucoside is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol 7-O-glucoside exhibits weak inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N4061

Hedycoronen A	Hedychium coronarium Koen. Structural Classification Terpenoids Source classification Diterpenoids Plants Zingiberaceae	Interleukin Related
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

Species:	Human (3) Marmoset (1) Rat (1) Mouse (2) Rabbit (1)
Tag:	His (7)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P73195

	*IL-23 alpha & IL-12* beta Heterodimer Protein, Rat (HEK293, His)** 2 Publications Verification IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Rat	HEK293
	IL-23 alpha protein has cytokine activity and binds to the interleukin 23 receptor. It regulates cytokine production, lymphocyte activation, and peptidyl tyrosine phosphorylation. IL-23 alpha & IL-12 beta Heterodimer Protein, Rat (HEK293, His) is a recombinant protein dimer complex containing rat-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293 , with C-10*His labeled tag. IL-23 alpha & IL-12 beta Heterodimer Protein, Rat (HEK293, His), has molecular weight of ~23 & 43 & 48 kDa, respectively.

HY-P73887

	*IL-23 alpha & IL-12* beta Heterodimer Protein, Rabbit (HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Rabbit	HEK293
	The IL-23 alpha protein, part of the IL-6 superfamily, comprises IL-23 alpha and IL-12 beta subunits forming a biologically active complex. It crucially influences the differentiation and activation of Th17 cells, associated with autoimmune diseases. The heterodimer stimulates pro-inflammatory cytokines like IL-17 and IL-22, promoting inflammation and immune cell recruitment. Dysregulation is linked to autoimmune diseases, making IL-23 alpha a potential therapeutic target for immune response modulation and inflammation control. IL-23 alpha & IL-12 beta Heterodimer Protein, Rabbit (HEK293, His) is a recombinant protein dimer complex containing Rabbit-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293, with C-His labeled tag. IL-23 alpha & IL-12 beta Heterodimer Protein, Rabbit (HEK293, His), has molecular weight of ~43 kDa & 23 kDa, respectively.

HY-P74874

	*Human IL-23 alpha & Mouse IL-12* beta Heterodimer Protein (HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Mouse;Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) is a recombinant protein dimer complex containing mouse, human-derived Human IL-23 alpha & Mouse IL-12 beta Heterodimer protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73193

	*IL-23 alpha (170a.a) & IL-12* beta (306a.a) Heterodimer Protein, Human (HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 alpha, expressed by HEK293 , with C-His labeled tag.

HY-P74814

	*IL-23 alpha (175a.a) & IL-12* beta (313a.a) Heterodimer Protein, Mouse (HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Mouse	HEK293
	IL-23 alpha, a crucial component, combines with IL12B to create the IL-23 interleukin, a heterodimeric cytokine pivotal in innate and adaptive immunity. Operating in peripheral tissues, IL-23, along with IL-17, responds acutely to infections. It binds to IL12RB1 and IL23R, activating Jak-Stat signaling, preferentially stimulating memory T-cells, and inducing pro-inflammatory cytokines. Released by antigen-presenting cells, IL-23 plays a role in autoimmune inflammation, contributing to autoimmune diseases and tumorigenesis, and supports the expansion of T-helper 17 cells. IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha, expressed by HEK293, with C-His labeled tag. IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293, His), has molecular weight of ~47 & 45 & 26 kDa, respectively.

HY-P73194

	*IL-23 alpha & IL-12* beta Heterodimer Protein, Marmoset (HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Marmoset	HEK293
	IL-23 alpha protein, a member of the IL-6 superfamily, is featured. IL-23 alpha & IL-12 beta Heterodimer Protein, Marmoset (HEK293, His) is a recombinant protein dimer complex containing Marmoset-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293 , with C-His labeled tag. IL-23 alpha & IL-12 beta Heterodimer Protein, Marmoset (HEK293, His), has molecular weight of ~22 & 45 kDa, respectively.

HY-P74816

	*IL-23 alpha (170a.a) & IL-12* beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Human	HEK293
	IL-23, collaborating with IL12B, constitutes the pro-inflammatory cytokine IL-23, crucial in innate and adaptive immunity. Released by antigen-presenting cells like dendritic cells or macrophages, IL-23 binds to IL12RB1 and IL23R, activating JAK2 and TYK2. This cascade phosphorylates STAT3 and STAT4, activating pathways like p38 MAPK or NF-kappa-B, inducing pro-inflammatory cytokines. IL-23 contributes to intracellular bacterial clearance and supports the expansion of T-helper 17 cells, including IL-17 producers. The disulfide-linked IL-23 interacts with IL12B and IL23R, recruiting IL12RB1. IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 alpha, expressed by HEK293, with C-His labeled tag. IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His), has molecular weight of ~55.8 kDa.

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Cat. No.	Product Name		Classification

HY-150741C

ODN 2216 sodium 1 Publications Verification		CpG ODNs
ODN 2216 sodium is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 sodium induces high amounts of IFN-α and IFN-β. ODN 2216 sodium induces IFN-α by pDC (plasmacytoid DC) and *IL-12 (p40)* production by DC (dendritic cells). ODN 2216 sodium stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 sodium can activate NK cells and promote IFN-γ production of TCR-triggered CD4 ⁺ T cells .

HY-160231

ssRNA42 sodium		CpG ODNs
ssRNA42 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA42 (sodium) derives from ssRNA40 by replacement of all G nucleotides with adenosine. ssRNA42 activated human PBMCs to secrete IFN-α, TNF-a, IL- 12p40, and IL-6, but ssRNA42 failed to stimulated murine pDCs and PBMCs.

HY-150741

ODN 2216		CpG ODNs
ODN 2216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and *IL-12 (p40)* production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4 ⁺ T cells .

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IL12p40

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