IL-23 alpha & IL-12 beta Heterodimer Protein, Rabbit (HEK293, His)

The IL-23 alpha protein, part of the IL-6 superfamily, comprises IL-23 alpha and IL-12 beta subunits forming a biologically active complex. It crucially influences the differentiation and activation of Th17 cells, associated with autoimmune diseases. The heterodimer stimulates pro-inflammatory cytokines like IL-17 and IL-22, promoting inflammation and immune cell recruitment. Dysregulation is linked to autoimmune diseases, making IL-23 alpha a potential therapeutic target for immune response modulation and inflammation control. IL-23 alpha & IL-12 beta Heterodimer Protein, Rabbit (HEK293, His) is a recombinant protein dimer complex containing Rabbit-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293, with C-His labeled tag. IL-23 alpha & IL-12 beta Heterodimer Protein, Rabbit (HEK293, His), has molecular weight of ~43 kDa & 23 kDa, respectively.

The IL-23 alpha protein belongs to the IL-6 superfamily, a group of cytokines with diverse functions in immune regulation and inflammation. This heterodimeric protein is composed of two subunits, IL-23 alpha and IL-12 beta, which combine to form a biologically active complex. IL-23 alpha plays a crucial role in the differentiation and activation of T-helper 17 (Th17) cells, a subset of CD4+ T cells involved in the pathogenesis of autoimmune diseases and chronic inflammation. It stimulates the production of pro-inflammatory cytokines, such as IL-17 and IL-22, and promotes tissue inflammation and immune cell recruitment. Dysregulation of IL-23 alpha has been implicated in various autoimmune diseases, making it an attractive target for therapeutic interventions aimed at modulating immune responses and controlling inflammation.

Immobilized Human IL-23 R at 10 μg/mL (100 μL/well) can bind Rabbit IL-23 alpha & IL-12 beta Heterodimer Protein, The ED₅₀ for this effect is 0.1880 μg/mL.

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  Immobilized Human IL-23 R at 10 μg/mL (100 μL/well) can bind Rabbit IL-23 alpha & IL-12 beta Heterodimer Protein, The ED₅₀ for this effect is 0.1880 μg/mL.

Rabbit

HEK293

C-His

G1SSM0 (V22-P191)&G1TBD7 (I23-N324)

100352065  [NCBI]&100354852  [NCBI]

Approximately 43 kDa & 23 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.