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Results for "

KPC

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125604
    WCK-4234

    		Beta-lactamase Bacterial Infection
    WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases .
    WCK-4234
  • HY-117974
    Durlobactam sodium
    1 Publications Verification

    ETX2514

    		 Bacterial Infection
    Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii .
    Durlobactam sodium
  • HY-109124A
    Taniborbactam hydrochloride
    5+ Cited Publications

    VNRX-5133 hydrochloride

    		 Beta-lactamase Bacterial Infection
    Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria .
    Taniborbactam hydrochloride
  • HY-16752
    Relebactam
    Maximum Cited Publications
    26 Publications Verification

    MK-7655

    		 Beta-lactamase Bacterial Infection
    Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .
    Relebactam
  • HY-150767
    KPC-2-IN-2

    		Bacterial Infection
    KPC-2-IN-2 (Compound 6c) is a potent Klebsiella pneumoniae carbapenemase (KPC-2) inhibitor (Ki=0.038 μM). KPC-2-IN-2 can enhance the activity of cefotaxime in KPC-2 expressing Escherichia coli .
    KPC-2-IN-2
  • HY-150766
    KPC-2-IN-1

    		Bacterial Infection
    KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with Ki of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics .
    KPC-2-IN-1
  • HY-170803
    KPC-IN-1

    		Bacterial Infection
    KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2 (IC50=8.3 nM). KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems. KPC causes significant bacterial resistance to carbapenem antibiotics .
    KPC-IN-1
  • HY-164360
    αVβ8-IN-1

    		Integrin Inflammation/Immunology Cancer
    αVβ8-IN-1 is a αVβ8 integrin inhibitor. αVβ8-IN-1 has been shown to inhibit the growth of tumors such as EMT6, CT26, KPC, and TKCC-10. αVβ8-IN-1 can be used in research related to idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP), and tumors .
    αVβ8-IN-1
  • HY-109124
    Taniborbactam

    VNRX-5133

    		 Beta-lactamase Bacterial Infection
    Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria .
    Taniborbactam
  • HY-161094
    Metallo-β-lactamase-IN-12

    		Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity .
    Metallo-β-lactamase-IN-12
  • HY-16752R
    Relebactam (Standard)

    MK-7655 (Standard)

    		 Beta-lactamase Bacterial Infection
    Relebactam (Standard) is the analytical standard of Relebactam. This product is intended for research and analytical applications. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .
    Relebactam (Standard)

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