2. Anti-infection
  3. Beta-lactamase Bacterial
  4. Relebactam

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.

For research use only. We do not sell to patients.

Relebactam Chemical Structure

Relebactam Chemical Structure

CAS No. : 1174018-99-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 132 In-stock
Solution
10 mM * 1 mL in Water USD 132 In-stock
Solid
1 mg USD 57 In-stock
5 mg USD 120 In-stock
10 mg USD 190 In-stock
25 mg USD 350 In-stock
50 mg USD 650 In-stock
100 mg USD 990 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 20 publication(s) in Google Scholar

Other Forms of Relebactam:

Relebactam Related Antibodies

Top Publications Citing Use of Products

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Metallo-β-lactamase

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity[1].

In Vitro

Relebactam combine with Imipenem demonstrates activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa[1].
Relebactam shows limited inhibition of Class D-producing bacteria and has antipseudomonal activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Relebactam Related Antibodies
Clinical Trial
Molecular Weight

348.38

Formula

C12H20N4O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(ON1[C@]2([H])CC[C@@H](C(NC3CCNCC3)=O)[N@@](C2)C1=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (358.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (143.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8704 mL 14.3521 mL 28.7043 mL
5 mM 0.5741 mL 2.8704 mL 5.7409 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (71.76 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.72%

COA (249 KB) HNMR (273 KB) RP-HPLC (244 KB) MS (176 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.8704 mL 14.3521 mL 28.7043 mL 71.7607 mL
5 mM 0.5741 mL 2.8704 mL 5.7409 mL 14.3521 mL
10 mM 0.2870 mL 1.4352 mL 2.8704 mL 7.1761 mL
15 mM 0.1914 mL 0.9568 mL 1.9136 mL 4.7840 mL
20 mM 0.1435 mL 0.7176 mL 1.4352 mL 3.5880 mL
25 mM 0.1148 mL 0.5741 mL 1.1482 mL 2.8704 mL
30 mM 0.0957 mL 0.4784 mL 0.9568 mL 2.3920 mL
40 mM 0.0718 mL 0.3588 mL 0.7176 mL 1.7940 mL
50 mM 0.0574 mL 0.2870 mL 0.5741 mL 1.4352 mL
60 mM 0.0478 mL 0.2392 mL 0.4784 mL 1.1960 mL
80 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8970 mL
100 mM 0.0287 mL 0.1435 mL 0.2870 mL 0.7176 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Relebactam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Relebactam1174018-99-5MK-7655MK7655MK 7655Beta-lactamaseBacterialβ-lactamaseImipenemEnterobacteriaceaeP. aeruginosaβ-lactamasesantibacterialInhibitorinhibitorinhibit

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