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KRN-7000

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-102022
    α-Galactosylceramide
    2 Publications Verification

    α-GalCer; KRN7000

    		 Others Inflammation/Immunology Cancer
    α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor) .
    α-Galactosylceramide
  • HY-159902
    KRN7000 analog 3

    		Interleukin Related Inflammation/Immunology Cancer
    KRN7000 analog 3 (Compound 14),α-GalCer (HY-102022) analogue with 4-phenoxy substitution, is a iNKT agonist. KRN7000 analog 3 induces higher levels of IL-2 cytokine secretion (range: 49.2-62.6 ng/mL) than a-GalCer (44.1 ng/mL) in mNK1.2 cells. KRN7000 analog 3 is promising for research of antitumor agents and vaccine adjuvants .
    KRN7000 analog 3
  • HY-163704
    KRN7000 analog 1

    		IFNAR Interleukin Related Inflammation/Immunology Cancer
    KRN7000 analog 1 exhibits good Th1-biased immune response through induction of interferon-γ (IFN-γ) and reduction of interleukin-4 (IL-4). KRN7000 analog 1 is potential as an antitumor agent and vaccine adjuvant .
    KRN7000 analog 1
  • HY-159874
    KRN7000 analog 2

    		Others Cancer
    KRN7000 analog 2 is a iNKT agonist, which is promising for research of antitumor agents and vaccine adjuvants.
    KRN7000 analog 2
  • HY-W414697
    4-Hydroxysphinganine (C17 base)

    D-Ribo-phytosphingosine (C17 base)

    		 Others Others
    4-Hydroxysphinganine C17 base (D-Ribo-phytosphingosine C17 base), also known as D-ribo-phytosphingosine or PHS, is a crucial compound present in the membranes of fungi, plants, bacteria, marine organisms, and mammalian tissues. It plays a vital role in preserving the structural integrity of membranes, regulating cellular growth, and mediating the heat stress response in yeast. Additionally, PHS serves as a precursor for the synthesis of important lipid mediators such as PHS 1-phosphate, inositol phosphorylceramide, and KRN7000 (the α-anomer of galactosylceramide). Furthermore, this phospholipid promotes keratinocyte differentiation, making it a valuable active ingredient in cosmetic formulations.
    4-Hydroxysphinganine (C17 base)

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