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LYG 409

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*LYG-409*	Molecular Glues	Cancer
LYG-409 is an orally active degrader of GSPT1. LYG-409 shows excellent anti-acute myeloid leukemia and prostate cancer in vivo with TGI of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells mediated by the degradation of GSPT1 with an IC₅₀ of 9.50 nM, with a DC₅₀ of 7.87 nM in vitro .

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