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MASH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (1) 5-HT Receptor (1) Endogenous Metabolite (1) FXR (2) Mitochondrial Metabolism (2) Mitophagy (1)
By Research Areas:	Inflammation/Immunology (1) Metabolic Disease (7)

7

Inhibitors & Agonists

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

3-sucCA 3-Succinylated cholic acid	Endogenous Metabolite	Metabolic Disease
3-sucCA (3-Succinylated cholic acid) is a microbial derived bile acid. 3-sucCA is a lumen-restricted metabolite and alleviates alleviates MAFL-MASH progression in mouse models by reshaping the gut microbiota, especially by promoting the growth of Akkermansia muciniphila. 3-sucCA levels are lower in patients with biopsy-proven MAFLD .

SHO1122147	Mitochondrial Metabolism	Metabolic Disease
SHO1122147 (Compound 7m) affects the mitochondrial electron transport chain, exhibits mitochondrial uncoupling activity (EC₅₀=3.6 μM), and increases the oxygen consumption rate (OCR=69%) and promotes cellular respiration. SHO1122147 is orally active, and can be used in reaearch of obesity and metabolic dysfunction-associated steatohepatitis (MASH) .

BE2647	Mitochondrial Metabolism	Metabolic Disease Inflammation/Immunology
BE2647 is a selective inhibitor for mitochondrial pyruvate carrier (MPC) with an EC₅₀ of 70 nM. BE2647 exhibits good metabolic stability in mouse liver microsomes. BE2647 can be used in research of metabolic diseases, non-alcoholic fatty liver disease (MASLD), or non-alcoholic steatohepatitis (MASH) .

SHS206	Mitophagy	Metabolic Disease
SHS206 (compound 6n) is an orally active mitochondrial uncoupler that reduces hepatic triglyceride levels. SHS206 exhibits in vivo efficacy in the GAN mouse model and shows inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH) .

FXR/HSD17B13 modulator 1	FXR 17β-HSD	Metabolic Disease
FXR/HSD17B13 modulator 1 (compound 6) is a potent modulator of FXR/HSD17B13. FXR/HSD17B13 modulator 1 plays an important roel in metabolic dysfunction-associated steatohepatitis (MASH) research .

5-HT2A antagonist 2	5-HT Receptor	Metabolic Disease
5HT2A antagonist 2 is an orally active, selective antagonist for 5HT_2A with IC₅₀ of 14 nM. 5-HT2A antagonist 2 exhibits good chemical, hepatocyte, and plasma stability, without significant cytotoxicity in cell lines VERO, HFL-1, L929, NIH3T3, CHO-K1 .

LZ-007	FXR	Metabolic Disease
LZ-007 is an agonist for farnesoid X receptor (FXR) with an EC₅₀ of 51 nM measuring by TR-FRET assay, or an EC₅₀ of 76 nM in HepG2 cell. LZ-007 exhibits good pharmacokinetic characheristics in SD rats. LZ-007 ameliorates western diet and CCl4 (HY-Y0298)-induced mice metabolic dysfunction-associated steatohepatitis

Cat. No.	Compare	Product Name	Application	Reactivity

	MASH1/Achaete-scute homolog 1 Antibody (YA1126) ASCL1; ASH1, BHLHA46; HASH1; Achaete-scute homolog 1; ASH-1; hASH1 ; Class A basic helix-loop-helix protein 46	IHC-P	Human
	MASH1/Achaete-scute homolog 1 Antibody (YA1126) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1126), targeting MASH1/Achaete-scute homolog 1. MASH1/Achaete-scute homolog 1 Antibody (YA1126) can be used for IHC-P experiment in human background.

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