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Results for "

MRTX 1719

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139611
    Navlimetostat
    3 Publications Verification

    MRTX-1719

    		 Histone Methyltransferase Cancer
    Navlimetostat is a potent, orally active, selective PRMT5•MTA complex inhibitor, with IC50 of 3.6 and 20.5 nM for PRMT5•MTA and PRMT5. Navlimetostat binds to the PRMT5•MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study .
    Navlimetostat
  • HY-139611C
    Navlimetostat hydrochloride
    3 Publications Verification

    MRTX-1719 hydrochloride

    		 Histone Methyltransferase Cancer
    Navlimetostat hydrochloride is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells .
    Navlimetostat hydrochloride
  • HY-139611B
    (S)-Navlimetostat

    (S)-MRTX-1719

    		 Histone Methyltransferase Cancer
    (S)-Navlimetostat (example 16-7) is the S-enantiomer of Navlimetostat. (S)-Navlimetostat is a PRMT5/MTA complex inhibitor, with an IC50 of 7070 nM .
    (S)-Navlimetostat

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