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Results for "

Mrc1

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

2

Recombinant Proteins

2

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107509
    LY2389575 hydrochloride

    		mGluR Neurological Disease
    LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease [1] .
    LY2389575 hydrochloride
  • HY-RS08641
    MRC1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MRC1 Human Pre-designed siRNA Set A contains three designed siRNAs for MRC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MRC1 Human Pre-designed siRNA Set A
    MRC1 Human Pre-designed siRNA Set A
  • HY-169859
    EP4 receptor antagonist 7

    		Prostaglandin Receptor Interleukin Related Inflammation/Immunology Cancer
    EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD 8+ T cells into tumors in a CT26 murine colon cancer model [1].
    EP4 receptor antagonist 7

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