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Pathways Recommended: NF-κB
Results for "

NF-κB-IN-4

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-144765
    NF-κB-IN-4
    1 Publications Verification

    		 NF-κB Apoptosis Neurological Disease Inflammation/Immunology
    NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research .
    NF-κB-IN-4
  • HY-173388
    Nitric oxide production-IN-2

    		Toll-like Receptor (TLR) JNK NF-κB Inflammation/Immunology
    TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is inhibitors of TLR4, JNK, and NF-κB. TLR4/JNK/NF-κB-IN-1 inhibits NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 23.2 µM. TLR4/JNK/NF-κB-IN-1 exerts anti-inflammatory activity by inhibiting TLR4 expression, reducing JNK phosphorylation, thereby suppressing the activation of NF-κB, blocking the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and decreasing the production of inflammatory mediators such as NO, PGE 2, and TNF-α. TLR4/JNK/NF-κB-IN-1 is promising for research of inflammatory diseases, such as rheumatoid arthritis and various inflammatory disorders .
    Nitric oxide production-IN-2