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Results for "

NKCC1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GABA Receptor (4) NKCC (9) Potassium Channel (4)
By Research Areas:	Cancer (4) Cardiovascular Disease (6) Metabolic Disease (8) Neurological Disease (3)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107321

Azosemide 3 Publications Verification	NKCC	Metabolic Disease
Azosemide, a sulfonamide loop diuretic, is a potent *NKCC1* inhibitor with IC₅₀s of 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B, respectively ^[1].

HY-17468

Bumetanide Maximum Cited Publications 9 Publications Verification Ro 10-6338; PF 1593	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide is a selective *NKCC1* inhibitor, but also inhibits NKCC2, with IC₅₀s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively ^[1] .

HY-17468S

Bumetanide-d5	NKCC	Cardiovascular Disease
Bumetanide-d₅ is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].

HY-16689

VU 0240551 1 Publications Verification	Potassium Channel	Others
VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC₅₀=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca ²⁺ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission ^[1] .

HY-B0135

Furosemide 2 Publications Verification	NKCC GABA Receptor	Cardiovascular Disease Metabolic Disease Cancer
Furosemide is a potent and orally active inhibitor of *Na ⁺/K ⁺/2Cl ^-?(NKCC)* cotransporter*, NKCC1* and NKCC2 ^[1].?Furosemide is also a GABA_A?receptors antagonist and displays 100-fold selectivity for?α6-containing receptors than?α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-B0135A

Furosemide sodium 2 Publications Verification	NKCC GABA Receptor	Cardiovascular Disease Metabolic Disease Cancer
Furosemide sodium is a potent and orally active inhibitor of *Na ⁺/K ⁺/2Cl ^- (NKCC)* cotransporter*, NKCC1* and NKCC2 ^[1]. Furosemide sodium is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-110143

CLP257	Potassium Channel	Neurological Disease
CLP257 is a selective K ⁺-Cl ^? cotransporter KCC2 activator with an EC₅₀ of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl ^? transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally ^[1] .

HY-B0135S

Furosemide-d5	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

HY-17468A

Bumetanide sodium Ro 10-6338 sodium; PF 1593 sodium	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide sodium, a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide sodium is a selective *NKCC1* inhibitor, and also inhibits NKCC2, with IC₅₀s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively ^[1] .

HY-17468R

Bumetanide (Standard) Ro 10-6338 (Standard); PF 1593 (Standard)	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide (Standard) is the analytical standard of Bumetanide. This product is intended for research and analytical applications. Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide is a selective *NKCC1* inhibitor, but also inhibits NKCC2, with IC₅₀s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively ^[1] .

HY-B0135R

Furosemide (Standard) 2 Publications Verification	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide (Standard) is the analytical standard of Furosemide. This product is intended for research and analytical applications. Furosemide is a potent and orally active inhibitor of *Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1* and NKCC2 ^[1]. Furosemide is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-18172A

(+)-KCC2 blocker 1	Potassium Channel	Neurological Disease
(+)-KCC2 blocker 1 is a selective K ⁺-Cl ^- cotransporter KCC2 blocker with an IC₅₀ of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1 ^[1].

HY-18172

KCC2 blocker 1	Potassium Channel	Neurological Disease
KCC2 blocker 1 is an orally active and selective K ⁺-Cl ^- cotransporter KCC2 blocker with an IC₅₀ of 1 μM. KCC2 blocker 1 is a benzyl prolinate ^[1].

Cat. No.	Product Name	Chemical Structure

HY-17468S

Bumetanide-d5
Bumetanide-d₅ is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].

HY-B0135S

Furosemide-d5
Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

Furosemide-d5

Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

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