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Results for "

NOTUM

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Recombinant Proteins

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147519
    ARUK3001185

    		Wnt Cancer
    ARUK3001185 (Compound 8l) is a potent, selective, orally active and brain-penetrant inhibitor of Notum activity with an IC50 of 6.7 nM .
    ARUK3001185
  • HY-142688
    Carboxylesterase-IN-2

    		Carboxylesterase Wnt Cancer
    Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease .
    Carboxylesterase-IN-2
  • HY-142689
    Carboxylesterase-IN-3

    		Carboxylesterase Wnt Cancer
    Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease .
    Carboxylesterase-IN-3
  • HY-131034
    LP-922056

    		Wnt Others
    LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats .
    LP-922056
  • HY-122832
    ABC99

    		Wnt Cancer
    ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM .
    ABC99
  • HY-148360
    Notum pectinacetylesterase-1

    		Others Others
    Notum pectinacetylesterase-1 is a potent inhibitor of notum pectinacetylesterase. Notum pectinacetylesterase-1 can be used for the research of disorders affecting the bone .
    Notum pectinacetylesterase-1
  • HY-W171983
    Notum-IN-1

    		Others Cancer
    Notum-IN-1 (compound 6b) is an orally active, selective and brain penetrant inhibitor of Notum. Notum-IN-1 blocks the Wnt signaling in vivo in mouse .
    Notum-IN-1
  • HY-RS09454
    NOTUM Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NOTUM Human Pre-designed siRNA Set A contains three designed siRNAs for NOTUM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NOTUM Human Pre-designed siRNA Set A
    NOTUM Human Pre-designed siRNA Set A
  • HY-149818
    8BTC

    		Wnt Cancer
    8BTC (compound 4w) is a potent covalent Notum inhibitor with IC50 of 2.5 nM .
    8BTC

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