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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

Nerve cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Akt (1) Aldehyde Dehydrogenase (ALDH) (2) Amyloid-β (1) Apoptosis (5) Bacterial (2) Biochemical Assay Reagents (1) Calcium Channel (1) Caspase (1) Cholinesterase (ChE) (1) Endogenous Metabolite (16) Ferroptosis (1) Fluorescent Dye (1) Fungal (2) iGluR (1) Interleukin Related (2) Isotope-Labeled Compounds (9) MAP3K (1) MAP4K (1) Mas-related G-protein-coupled Receptor (MRGPR) (2) MMP (1) Neurokinin Receptor (1) Neurotensin Receptor (1) NF-κB (2) NO Synthase (1) Phosphatase (1) Potassium Channel (8) Reactive Oxygen Species (3) RIP kinase (1) ROCK (1) Sodium Channel (8) TNF Receptor (2)
By Research Areas:	Cancer (15) Cardiovascular Disease (12) Infection (8) Inflammation/Immunology (7) Metabolic Disease (7) Neurological Disease (45)
Oligonucleotides:	Solubilizing Agents (1) Freeze-drying Protective Agents (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Nuclear Hormone Receptor 4A/NR4A Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3 BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4285

Negletein 5,6-Dihydroxy-7-methoxyflavone	NO Synthase TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC₅₀ values of 16.4 and 10.8 μM, respectively .

HY-P3419

PAMP-12 (unmodified)	Mas-related G-protein-coupled Receptor (MRGPR)	Cardiovascular Disease
PAMP-12 (unmodified) is a potent MRGPRX2 (MrgX2) agonist (EC₅₀=20-50 nM). PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells .

HY-W017443

L-Asparagine monohydrate 3 Publications Verification	Endogenous Metabolite	Metabolic Disease
L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-A0079

Tetracaine Amethocaine	Sodium Channel	Neurological Disease
Tetracaine is a long-acting amino-ester used to prevent pain and induce anesthesia for the eyes; works by interfering with entry of sodium ions into nerve cells.

HY-N0667

L-Asparagine 3 Publications Verification (-)-Asparagine; Asn; Asparamide	Endogenous Metabolite	Neurological Disease Cancer
L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity .

HY-N0667S5

L-Asparagine-d3 hydrate	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Asparagine-d₃ (hydrate) is the deuterium labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N12170

Kissoone C	Others	Neurological Disease
Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .

HY-117517

NG-012	Others	Cancer
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

HY-11055

KP 544	Others	Neurological Disease
KP 544 is a potent neurotrophic protein enhancer that amplifies nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells and SH-SY5Y neuroblastoma cells. KP544 also enhances choline acetyltransferase activity. KP 544 selectively interact in the differentiation pathway downstream of MAPK in a manner that amplifies nerve growth factor and cyclic AMP effects and is also neuroprotective .

HY-N2629

Erigoster B	Others	Neurological Disease
Erigoster B is the active component of Erigeron breviscapus (Vant.) Hand.-Mazz. (an important Chinese herb), which has neuroprotective effects. Erigoster B can be used to prepare anti-nerve damage reagents to inhibit various nerve cell damage. It can also be used for cardio-cerebrovascular and tumor research .

HY-N3938

Gelsemiol	Others	Neurological Disease
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

HY-N8931

Monomethyl lithospermate Lithospermic acid monomethyl ester	Akt	Neurological Disease
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) .

HY-N0667S2

L-Asparagine-15N2 monohydrate (-)-Asparagine-¹⁵N₂ monohydrate; Asn-¹⁵N₂ monohydrate; Asparamide-¹⁵N₂ monohydrate	Endogenous Metabolite	Neurological Disease
L-Asparagine- ¹⁵N₂ (monohydrate) is the ¹⁵N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443S1

L-Asparagine-amide-15N monohydrate	Endogenous Metabolite	Metabolic Disease
L-Asparagine-amide- ¹⁵N (monohydrate) is the ¹⁵N-labeled L-Asparagine (monohydrate). L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0667S3

L-Asparagine-13C4 monohydrate (-)-Asparagine-¹³C₄ monohydrate; Asn-¹³C₄ monohydrate; Asparamide-¹³C₄ monohydrate	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Asparagine- ¹³C₄ (monohydrate) is the ¹³C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0667S4

L-Asparagine-4-13C monohydrate (-)-Asparagine-4-¹³C monohydrate; Asn-4-¹³C monohydrate; Asparamide-4-¹³C monohydrate	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Asparagine-4- ¹³C (monohydrate) is the ¹³C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443R

L-Asparagine monohydrate (Standard)	Endogenous Metabolite	Metabolic Disease
L-Asparagine (monohydrate) (Standard) is the analytical standard of L-Asparagine (monohydrate). This product is intended for research and analytical applications. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0015

Astragalin 5 Publications Verification Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside	Apoptosis NF-κB	Infection Inflammation/Immunology Cancer
Astragalin (Astragaline) a flavonoid with anti-inflammatory, antioxidant, anticancer, bacteriostatic activity. Astragalin inhibits cancer cells proliferation and migration, induces apoptosis. Astragalin is orally active and provides nerve and heart protection, and resistance against and osteoporosis .

HY-N3928

Garciniaxanthone E	Others	Neurological Disease
Garciniaxanthone E is a xanthone compound. Garciniaxanthone E significantly enhances cellular nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells. Garciniaxanthone E contributes to basic research and medicinal development in neurodegenerative diseases .

HY-106933A

Dabelotine methanesulfonate S 12024-2	Others	Neurological Disease
Dabelotine (methanesulfonate) is a cognitive enhancer. Dabelotine (methanesulfonate) can be used for Alzheimer disease (AD) research .

HY-N0667S1

L-Asparagine-15N2,d8	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Asparagine- ¹⁵N₂,d₈ is the ¹⁵N- and deuterium labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443S3

L-Asparagine-15N2,d3 monohydrate	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Asparagine- ¹⁵N₂,d₃ (monohydrate) is the deuterium and ¹⁵N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443S4

L-Asparagine-1,2,3,4-13C4 monohydrate	Endogenous Metabolite	Metabolic Disease
L-Asparagine-1,2,3,4- ¹³C₄ (monohydrate) is the ¹³C labeled L-Asparagine (monohydrate)[1]. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443S

L-Asparagine-13C4,15N2 monohydrate	Endogenous Metabolite	Metabolic Disease
L-Asparagine- ¹³C₄, ¹⁵N₂ (monohydrate)is the ¹³C-labeled and ¹⁵N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N12141

Flaccidoside II	Apoptosis	Inflammation/Immunology
Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome .

HY-136395

Cartap	Reactive Oxygen Species	Infection
Cartap, an organonitrogen insecticide, can cause a marked irreversible Ca ²⁺-dependent contracture in both isolated mouse and rabbit phrenic nerve-diaphragms. Cartap significantly increases the level of endogenous reactive oxygen species (ROS) in C2C12 cells .

HY-W040028

Cartap hydrochloride	Reactive Oxygen Species	Infection
Cartap hydrochloride, an organonitrogen insecticide, can cause a marked irreversible Ca ²⁺-dependent contracture in both isolated mouse and rabbit phrenic nerve-diaphragms. Cartap hydrochloride significantly increases the level of endogenous reactive oxygen species (ROS) in C2C12 cells .

HY-148787

Oditrasertib SAR443820; DNL788	RIP kinase	Neurological Disease Inflammation/Immunology
Oditrasertib (SAR443820) is an orally active and brain-penetrant receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC₅₀ value lower than 100 nM. Oditrasertib could make nerve cells more resistant to the pathology and slow down the disease. Oditrasertib can be used for the research of neurodegenerative diseases involving inflammation or cell death .

HY-W017443S2

L-Asparagine-13C4,15N2,d3 monohydrate	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Asparagine- ¹³C₄, ¹⁵N₂,d₃ (monohydrate) is the deuterium, ¹³C-, and 15-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-P3419A

PAMP-12 (unmodified) (TFA)	Mas-related G-protein-coupled Receptor (MRGPR)	Cardiovascular Disease
PAMP-12 (unmodified) TFA is a potent MRGPRX2 (MrgX2) agonist (EC₅₀=20-50 nM). PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells .

HY-110166

PD 90780 1 Publications Verification	Others	Neurological Disease
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75 ^NTR. PD 90780 inhibits NGF-p75 ^NTR interaction with IC₅₀s of 23.1 and 1.8 µM in PC12 cells and PC12 ^nnr5 cells, respectively .

HY-B0600

Tafluprost AFP-168; MK2452	Others	Cardiovascular Disease Others
Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn ²⁺-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma .

HY-N0667S

L-Asparagine-13C4,15N2,d8	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Asparagine- ¹³C₄, ¹⁵N₂,d₈ is the ¹³C-labeled and ¹⁵N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0015R

Astragalin (Standard)	Apoptosis NF-κB	Infection Inflammation/Immunology Cancer
Astragalin (Standard) is the analytical standard of Astragalin. This product is intended for research and analytical applications. Astragalin (Astragaline) a flavonoid with anti-inflammatory, antioxidant, anticancer, bacteriostatic activity. Astragalin inhibits cancer cells proliferation and migration, induces apoptosis. Astragalin is orally active and provides nerve and heart protection, and resistance against and osteoporosis .

HY-W247131

DASPEI	Fluorescent Dye	Neurological Disease
DASPEI is a cationic styrenyl mitochondrial dye with large Stokes shift. DASPEI has excitation and emission wavelength at 550/573 nm, which has good light chromogenic property. DASPEI can stain mitochondria in living cells with good labeling property. And DASPEI can also be used to stain presynaptic nerve endings independently of neuronal activity .

HY-157978

AChE-IN-59	Cholinesterase (ChE) Amyloid-β	Neurological Disease
AChE-IN-59 (compounds 3b) is an AChE inhibitor, with an IC₅₀ value of 0.05 μM. AChE-IN-59 can inhibit the aggregation of Aβ1-42, protect nerve cells and penetrate the blood-brain barrier well. AChE-IN-59 can be used for the research of Alzheimer's disease (AD) .

HY-10068

Y-33075 hydrochloride Y-39983	ROCK	Neurological Disease
Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC₅₀ of 3.6 nM.

HY-W040028R

Cartap hydrochloride (Standard)	Reactive Oxygen Species	Infection
Cartap (hydrochloride) (Standard) is the analytical standard of Cartap (hydrochloride). This product is intended for research and analytical applications. Cartap hydrochloride, an organonitrogen insecticide, can cause a marked irreversible Ca2+-dependent contracture in both isolated mouse and rabbit phrenic nerve-diaphragms. Cartap hydrochloride significantly increases the level of endogenous reactive oxygen species (ROS) in C2C12 cells .

HY-N0667R

L-Asparagine (Standard)	Endogenous Metabolite	Neurological Disease Cancer
L-Asparagine (Standard) is the analytical standard of L-Asparagine. This product is intended for research and analytical applications. L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity . In Vitro:L-Asparagine (0.03 mM) can reverse the proliferation decline of six human cancer cells induced by ASNS siRNA knockdown . L-Asparagine (10 mM, 4 h) can stimulate ODC activity and proliferation in IPEC-J2 cells .

HY-N7018

20-Hydroxyganoderic Acid G	Others	Inflammation/Immunology
20-Hydroxyganoderic Acid G is a lanostane triterpenoid obtained from the EtOH extract of fruiting bodies of the Ganoderma curtisii. 20-Hydroxyganoderic Acid G inhibits BV-2 microglia cells activated by LPS with an IC₅₀ of 21.33 μM. 20-Hydroxyganoderic Acid G has therapeutic potential in the agent discovery of nerve inflammation diseases associated with microglia activated by LPS .

HY-B0600R

Tafluprost (Standard)	Others	Cardiovascular Disease Others
Tafluprost (Standard) is the analytical standard of Tafluprost. This product is intended for research and analytical applications. Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma [4] .

HY-B0563B

Ropivacaine hydrochloride 5 Publications Verification	Sodium Channel Potassium Channel	Cardiovascular Disease Neurological Disease Cancer
Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is widely used for neuropathic pain management in vivo .

HY-B0563

Ropivacaine 5 Publications Verification	Sodium Channel Potassium Channel	Cardiovascular Disease Neurological Disease Cancer
Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is used for the research of neuropathic pain management .

HY-B1661

Hexamethonium chloride Hexone chloride	Biochemical Assay Reagents	Cardiovascular Disease Others
Hexamethonium Chloride Dihydrate is a synthetic organic compound commonly used as a ganglion blocking agent, which means it blocks the transmission of nerve impulses between ganglion cells in the autonomic nervous system. Hexamethonium Chloride Dihydrate is used in various medical applications such as lowering blood pressure or inhibiting certain types of neuropathic pain. It works by inhibiting the release of acetylcholine, a neurotransmitter that plays a key role in regulating many bodily functions.

HY-135228

GZ4	Others	Neurological Disease
GZ4 is a calcium current inhibitor with direct inhibitory activity on cell surface channels. GZ4 inhibition reverses mechanical hyperalgesia/hyperalgesia in a spinal nerve ligation-induced neuropathic pain model. The mechanism of action of GZ4 is similar to that of gabapentin, but the time course of its biological effects is more rapid, indicating that GZ4 can directly inhibit calcium channel currents .

HY-N12172

Kissoone A	Others	Others
Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

HY-B0364A

Dyclonine hydrochloride 1 Publications Verification Dyclocaine hydrochloride	Bacterial Fungal Aldehyde Dehydrogenase (ALDH)	Infection Cancer
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC₅₀ of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain .

HY-B0563A

Ropivacaine hydrochloride monohydrate 5 Publications Verification	Sodium Channel Potassium Channel	Cardiovascular Disease Neurological Disease Cancer
Ropivacaine hydrochloride monohydrate is a potent?sodium channel?blocker and blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is widely used for regional anesthesia and neuropathic pain?management in vivo .

HY-106644

Femoxetine FG4963 free acid	5-HT Receptor	Neurological Disease
Femoxetine is a serotonin (5-HT) inhibitor with antidepressant properties. Femoxetine increases serotonin levels in the brain by preventing serotonin from being reabsorbed by nerve cells, resulting in increased concentrations of the neurotransmitter in the synaptic gap, which enhances serotonin signaling. Femoxetine can be used to study the role of serotonin in depression and other emotional disorders, and how 5-HT reuptake inhibitors affect mood and behavior .

HY-106644A

Femoxetine hydrochloride FG4963	5-HT Receptor	Neurological Disease
Femoxetine hydrochloride is a serotonin (5-HT) inhibitor with antidepressant properties. Femoxetine hydrochloride increases serotonin levels in the brain by preventing serotonin from being reabsorbed by nerve cells, resulting in increased concentrations of the neurotransmitter in the synaptic gap, which enhances serotonin signaling. Femoxetine hydrochloride can be used to study the role of serotonin in depression and other emotional disorders, and how 5-HT reuptake inhibitors affect mood and behavior .

Cat. No.	Product Name

HY-L086

Neurodegenerative Disease-related Compound Library

2,435 compounds

Neurodegenerative diseases are incurable and life-threatening conditions that result in progressive degeneration and/or death of nerve cells. Some common neurodegenerative diseases include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Motor Neuron Disease (MND), Huntington’s Disease (HD), Spino-Cerebellar Ataxia (SCA), Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Because the pathophysiology of neurodegenerative disorders is generally poorly understood, it is difficult to identify promising molecular targets and validate them. At the same time, about 85% of the drugs fail in clinical trials. Therefore, validating new targets and discovering new drugs to mitigate neurodegenerative disorders is need of the hour.

MCE offers a unique collection of 2,435 compounds with anti-Neurodegenerative Diseases activities or targeting the unique targets of neurodegenerative diseases. MCE Neurodegenerative Disease-related Compound Library is a useful tool for exploring the mechanism of neurodegenerative diseases and discovering new drugs for neurodegenerative diseases.

HY-L040

Anti-diabetic Compound Library

793 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 793 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Cat. No.	Product Name	Type

HY-W247131

DASPEI	Fluorescent Dyes/Probes
DASPEI is a cationic styrenyl mitochondrial dye with large Stokes shift. DASPEI has excitation and emission wavelength at 550/573 nm, which has good light chromogenic property. DASPEI can stain mitochondria in living cells with good labeling property. And DASPEI can also be used to stain presynaptic nerve endings independently of neuronal activity .

HY-W751874

Acetyl methylene blue	Dyes
Acetyl methylene blue can be used to synthesize mitochondrial development stimulators, which can be used for eye diseases related to insufficient mitochondrial function in nerve cells .

Cat. No.	Product Name	Type

HY-W698686

β-Galactosyl-C18-ceramide

Cell Assay Reagents

β-Galactosyl-C18-ceramide is a bioactive molecule that promotes the regulation of nerve cells, regulates protein kinase C activity, and affects hormone receptors. β-Galactosyl-C18-ceramide is widely used in neuroscience research to explore its effects on nerve cell growth and function. The regulatory function of β-Galactosyl-C18-ceramide makes it a potential application prospect in compound development and disease inhibition.

HY-B1661

Hexamethonium chloride

Hexone chloride

Biochemical Assay Reagents

Hexamethonium Chloride Dihydrate is a synthetic organic compound commonly used as a ganglion blocking agent, which means it blocks the transmission of nerve impulses between ganglion cells in the autonomic nervous system. Hexamethonium Chloride Dihydrate is used in various medical applications such as lowering blood pressure or inhibiting certain types of neuropathic pain. It works by inhibiting the release of acetylcholine, a neurotransmitter that plays a key role in regulating many bodily functions.

Cat. No.	Product Name	Target	Research Area

HY-P3419

PAMP-12 (unmodified)	Mas-related G-protein-coupled Receptor (MRGPR)	Cardiovascular Disease
PAMP-12 (unmodified) is a potent MRGPRX2 (MrgX2) agonist (EC₅₀=20-50 nM). PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells .

HY-P5806

Ergtoxin-1 ErgTx1	Peptides	Neurological Disease
Ergtoxin-1 is a potassium channel blocker. Ergtoxin-1 is isolated from the venom of the Mexican scorpion Centruroides noxius. Ergtoxin 1 can block ERG-K ⁺ channels in nerve, heart and endocrine cells .

HY-P3419A

PAMP-12 (unmodified) (TFA)	Mas-related G-protein-coupled Receptor (MRGPR)	Cardiovascular Disease
PAMP-12 (unmodified) TFA is a potent MRGPRX2 (MrgX2) agonist (EC₅₀=20-50 nM). PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4285

Negletein 5,6-Dihydroxy-7-methoxyflavone	Structural Classification Flavonoids Flavones Labiatae Source classification Phenols Polyphenols Plants Medicago truncatula Gaertn.	NO Synthase TNF Receptor Interleukin Related
Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC₅₀ values of 16.4 and 10.8 μM, respectively .

HY-W017443

L-Asparagine monohydrate 3 Publications Verification	Structural Classification Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0667

L-Asparagine 3 Publications Verification (-)-Asparagine; Asn; Asparamide	Structural Classification Neurological Disease Classification of Application Fields Source classification Amino acids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity .

HY-N0015

Astragalin 5 Publications Verification Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside	Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids Microorganisms Phenols Polyphenols Disease Research Fields Thesium chinense Turcz. Santalaceae Cancer	Apoptosis NF-κB
Astragalin (Astragaline) a flavonoid with anti-inflammatory, antioxidant, anticancer, bacteriostatic activity. Astragalin inhibits cancer cells proliferation and migration, induces apoptosis. Astragalin is orally active and provides nerve and heart protection, and resistance against and osteoporosis .

HY-N12170

Kissoone C	Structural Classification Terpenoids Sesquiterpenes Source classification Valeriana officinalis Linn. Plants Valerianaceae	Others
Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .

HY-117517

NG-012	Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	Others
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

HY-N2629

Erigoster B	Structural Classification Source classification Phenols Polyphenols Plants Compositae Erigeron breviscapus (Vant.) Hand.-Mazz.	Others
Erigoster B is the active component of Erigeron breviscapus (Vant.) Hand.-Mazz. (an important Chinese herb), which has neuroprotective effects. Erigoster B can be used to prepare anti-nerve damage reagents to inhibit various nerve cell damage. It can also be used for cardio-cerebrovascular and tumor research .

HY-N3938

Gelsemiol	Structural Classification Iridoids Terpenoids Source classification Populus tomentosa Plants Salicaceae	Others
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

HY-N8931

Monomethyl lithospermate Lithospermic acid monomethyl ester	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Akt
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) .

HY-W017443R

L-Asparagine monohydrate (Standard)	Structural Classification Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
L-Asparagine (monohydrate) (Standard) is the analytical standard of L-Asparagine (monohydrate). This product is intended for research and analytical applications. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N3928

Garciniaxanthone E	Structural Classification Flavonoids Garcinia xanthochymus Hook. f. ex T. Anders. Flavonones Source classification Guttiferae Plants	Others
Garciniaxanthone E is a xanthone compound. Garciniaxanthone E significantly enhances cellular nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells. Garciniaxanthone E contributes to basic research and medicinal development in neurodegenerative diseases .

HY-N12141

Flaccidoside II	Structural Classification Polysaccharides Anemone flaccida Fr. Schmidt Source classification Ranunculaceae Plants Saccharides	Apoptosis
Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome .

HY-B0600

Tafluprost AFP-168; MK2452	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Others
Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn ²⁺-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma .

HY-N0015R

Astragalin (Standard)	Flavonols Structural Classification Flavonoids Microorganisms Source classification Phenols Polyphenols Plants Thesium chinense Turcz. Santalaceae	Apoptosis NF-κB
Astragalin (Standard) is the analytical standard of Astragalin. This product is intended for research and analytical applications. Astragalin (Astragaline) a flavonoid with anti-inflammatory, antioxidant, anticancer, bacteriostatic activity. Astragalin inhibits cancer cells proliferation and migration, induces apoptosis. Astragalin is orally active and provides nerve and heart protection, and resistance against and osteoporosis .

HY-N0667R

L-Asparagine (Standard)	Structural Classification Immune System Disorder Microorganisms Source classification Disease markers Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Endogenous Metabolite
L-Asparagine (Standard) is the analytical standard of L-Asparagine. This product is intended for research and analytical applications. L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity . In Vitro:L-Asparagine (0.03 mM) can reverse the proliferation decline of six human cancer cells induced by ASNS siRNA knockdown . L-Asparagine (10 mM, 4 h) can stimulate ODC activity and proliferation in IPEC-J2 cells .

HY-N7018

20-Hydroxyganoderic Acid G	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Inflammation/Immunology Disease Research Fields	Others
20-Hydroxyganoderic Acid G is a lanostane triterpenoid obtained from the EtOH extract of fruiting bodies of the Ganoderma curtisii. 20-Hydroxyganoderic Acid G inhibits BV-2 microglia cells activated by LPS with an IC₅₀ of 21.33 μM. 20-Hydroxyganoderic Acid G has therapeutic potential in the agent discovery of nerve inflammation diseases associated with microglia activated by LPS .

HY-B1661

Hexamethonium chloride Hexone chloride	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Biochemical Assay Reagents
Hexamethonium Chloride Dihydrate is a synthetic organic compound commonly used as a ganglion blocking agent, which means it blocks the transmission of nerve impulses between ganglion cells in the autonomic nervous system. Hexamethonium Chloride Dihydrate is used in various medical applications such as lowering blood pressure or inhibiting certain types of neuropathic pain. It works by inhibiting the release of acetylcholine, a neurotransmitter that plays a key role in regulating many bodily functions.

HY-N12172

Kissoone A	Structural Classification Terpenoids Sesquiterpenes Source classification Valeriana officinalis Linn. Plants Valerianaceae	Others
Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

HY-14608R

L-Glutamic acid (Standard)	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Endogenous Metabolite iGluR Ferroptosis Apoptosis
L-Glutamic acid (Standard) is the analytical standard of L-Glutamic acid. This product is intended for research and analytical applications. L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases . IC₅₀ & Target:DA . In Vitro: L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus . L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma . In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice . L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .

Species:	Human (1) Mouse (1)
Tag:	His (2) Avi (1)
Source:	HEK293 (1) E. coli Cell-free (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P702385

	NINJ1 Protein, Mouse (Cell-Free, His) Ninjurin-1; Nerve injury-induced protein 1	Mouse	E. coli Cell-free
	The NINJ1 protein is an important mediator of programmed cell death, inducing plasma membrane rupture in necroptosis and pyroptosis. NINJ1 is activated by Gasdermin or MLKL, oligomerizes, releases DAMPs and exacerbates inflammation. NINJ1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived NINJ1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of NINJ1 Protein, Mouse (Cell-Free, His) is 152 a.a., with molecular weight of 19&35&57&76&114 kDa.

HY-P78091

	CD40 Protein, Human (Biotinylated, HEK293, His-Avi) CD40; CD40L receptor; TNFRSF5; B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CDw40; MGC9013; Nerve growth factor receptor-relat	Human	HEK293
	CD40 protein is a TNFSF5/CD40LG receptor that transduces signals through TRAF6 and MAP3K8-mediated pathways, activates ERK in macrophages and B cells, and induces immunoglobulin secretion. CD40 exists as monomers and homodimers and interacts with TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6). CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD40 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is 173 a.a., with molecular weight of 35-40 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-N0667S5

L-Asparagine-d3 hydrate
L-Asparagine-d₃ (hydrate) is the deuterium labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0667S2

L-Asparagine-15N2 monohydrate
L-Asparagine- ¹⁵N₂ (monohydrate) is the ¹⁵N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443S1

L-Asparagine-amide-15N monohydrate
L-Asparagine-amide- ¹⁵N (monohydrate) is the ¹⁵N-labeled L-Asparagine (monohydrate). L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443S

L-Asparagine-13C4,15N2 monohydrate
L-Asparagine- ¹³C₄, ¹⁵N₂ (monohydrate)is the ¹³C-labeled and ¹⁵N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443S2

L-Asparagine-13C4,15N2,d3 monohydrate
L-Asparagine- ¹³C₄, ¹⁵N₂,d₃ (monohydrate) is the deuterium, ¹³C-, and 15-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0667S3

L-Asparagine-13C4 monohydrate
L-Asparagine- ¹³C₄ (monohydrate) is the ¹³C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0667S4

L-Asparagine-4-13C monohydrate
L-Asparagine-4- ¹³C (monohydrate) is the ¹³C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0667S1

L-Asparagine-15N2,d8
L-Asparagine- ¹⁵N₂,d₈ is the ¹⁵N- and deuterium labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443S3

L-Asparagine-15N2,d3 monohydrate
L-Asparagine- ¹⁵N₂,d₃ (monohydrate) is the deuterium and ¹⁵N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W017443S4

L-Asparagine-1,2,3,4-13C4 monohydrate
L-Asparagine-1,2,3,4- ¹³C₄ (monohydrate) is the ¹³C labeled L-Asparagine (monohydrate)[1]. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0667S

L-Asparagine-13C4,15N2,d8
L-Asparagine- ¹³C₄, ¹⁵N₂,d₈ is the ¹³C-labeled and ¹⁵N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-B0563S1

Ropivacaine-d7

Ropivacaine-d₇ is deuterium labeled Ropivacaine. Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of neuropathic pain management[1].

HY-B0563BS

Ropivacaine-d7 hydrochloride

Ropivacaine-d₇ hydrochloride is a deuterium labeled Ropivacaine (hydrochloride) (HY-B0563B) . Ropivacaine hydrochloride is a potent?sodium channel?blocker and blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is widely used for neuropathic pain?management in vivo .

Cat. No.	Product Name		Classification

HY-N0667

L-Asparagine 3 Publications Verification (-)-Asparagine; Asn; Asparamide		Freeze-drying Protective Agents Solubilizing Agents
L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity .

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