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  4. PD 90780

PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively .

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PD 90780 Chemical Structure

PD 90780 Chemical Structure

CAS No. : 77422-99-2

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Based on 1 publication(s) in Google Scholar

PD 90780 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PD 90780

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively[1] .

IC50 & Target

IC50: 23.1 µM (NGF-p75NTR, PC12 cells), 1.8 µM (NGF-p75NTR, PC12nnr5 cells)[1]
In Vitro

PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR[1].
PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR[1].
PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM[1].
PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 µM and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD 90780 Related Antibodies
Molecular Weight

362.34

Formula

C19H14N4O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1C2=CC(C(O)=O)=NN2C(C3=CC(NC(C4=CC=CC=C4)=O)=CC=C13)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (86.24 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7598 mL 13.7992 mL 27.5984 mL
5 mM 0.5520 mL 2.7598 mL 5.5197 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (245 KB) Elemental Analysis Report (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7598 mL 13.7992 mL 27.5984 mL 68.9960 mL
5 mM 0.5520 mL 2.7598 mL 5.5197 mL 13.7992 mL
10 mM 0.2760 mL 1.3799 mL 2.7598 mL 6.8996 mL
15 mM 0.1840 mL 0.9199 mL 1.8399 mL 4.5997 mL
20 mM 0.1380 mL 0.6900 mL 1.3799 mL 3.4498 mL
25 mM 0.1104 mL 0.5520 mL 1.1039 mL 2.7598 mL
30 mM 0.0920 mL 0.4600 mL 0.9199 mL 2.2999 mL
40 mM 0.0690 mL 0.3450 mL 0.6900 mL 1.7249 mL
50 mM 0.0552 mL 0.2760 mL 0.5520 mL 1.3799 mL
60 mM 0.0460 mL 0.2300 mL 0.4600 mL 1.1499 mL
80 mM 0.0345 mL 0.1725 mL 0.3450 mL 0.8624 mL
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PD 90780 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD 9078077422-99-2PD90780PD-90780OthersTrkABDNFp75phosphorylationneurotrophininteractionInhibitorinhibitorinhibit

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