3,4-Dephostatin (Synonyms: Methyl-3,4-dephostatin)

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3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase). 3,4-Dephostatin accelerates nerve growth factor (NGF)-induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activated protein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF)-induced tyrosine phosphorylation and activation of MAP kinase.

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3,4-Dephostatin Chemical Structure

CAS No. : 173043-84-0

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Description	3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase). 3,4-Dephostatin accelerates nerve growth factor (NGF)-induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activated protein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF)-induced tyrosine phosphorylation and activation of MAP kinase^[1].
Molecular Weight	168.15
Formula	C₇H₈N₂O₃
CAS No.	173043-84-0
SMILES	OC1=CC=C(N(C)N=O)C=C1O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Fujiwara S, et al. Enhancement or induction of neurite formation by a protein tyrosine phosphatase inhibitor, 3,4-dephostatin, in growth factor-treated PC12h cells. Biochem Biophys Res Commun. 1997 Sep 8;238(1):213-7. [Content Brief]

3,4-Dephostatin Related Classifications

Neurological Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,4-Dephostatin173043-84-0Methyl-3,4-dephostatinMAP3KMAP4KPhosphataseMAP kinase kinase kinase, MEKK, MAPKKKMAPK Kinase Kinase KinasePTPaseNGFneurite formationPC12h cellstyrosine phosphorylationMAPEGFInhibitorinhibitorinhibit

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