2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. LM11A-31

LM11A-31, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

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LM11A-31 Chemical Structure

LM11A-31 Chemical Structure

CAS No. : 102562-74-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 7 publication(s) in Google Scholar

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Description

LM11A-31, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression[1][2].

In Vivo

LM11A-31 (oral gavage; 50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity[1].
LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 J mice[1].
Dosage: 50 mg kg/day
Administration: Oral gavage; for 4 weeks
Result: Mitigated proNGF accumulation and preserved BRB integrity.
Molecular Weight

243.35

Formula

C12H25N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@H](N)C(NCCN1CCOCC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (479.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1093 mL 20.5465 mL 41.0931 mL
5 mM 0.8219 mL 4.1093 mL 8.2186 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1093 mL 20.5465 mL 41.0931 mL 102.7327 mL
5 mM 0.8219 mL 4.1093 mL 8.2186 mL 20.5465 mL
10 mM 0.4109 mL 2.0547 mL 4.1093 mL 10.2733 mL
15 mM 0.2740 mL 1.3698 mL 2.7395 mL 6.8488 mL
20 mM 0.2055 mL 1.0273 mL 2.0547 mL 5.1366 mL
25 mM 0.1644 mL 0.8219 mL 1.6437 mL 4.1093 mL
30 mM 0.1370 mL 0.6849 mL 1.3698 mL 3.4244 mL
40 mM 0.1027 mL 0.5137 mL 1.0273 mL 2.5683 mL
50 mM 0.0822 mL 0.4109 mL 0.8219 mL 2.0547 mL
60 mM 0.0685 mL 0.3424 mL 0.6849 mL 1.7122 mL
80 mM 0.0514 mL 0.2568 mL 0.5137 mL 1.2842 mL
100 mM 0.0411 mL 0.2055 mL 0.4109 mL 1.0273 mL
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LM11A-31 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LM11A-31102562-74-3Neurokinin ReceptorNK receptorTachykinin receptorp75neurotrophin receptorHIVAlzheimer's diseaseInhibitorinhibitorinhibit

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