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Nicotiana

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Apoptosis (1) Cholinesterase (ChE) (1) Complement System (1) Cytochrome P450 (1) Drug Derivative (1) Drug Metabolite (5) EBV (1) Endogenous Metabolite (2) Herbicide (4) nAChR (3) Protoporphyrinogen IX oxidase (5)
By Research Areas:	Cancer (1) Infection (1) Metabolic Disease (2) Neurological Disease (9)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8723

(1′S,2′S)-Nicotine-1'-oxide	Others	Neurological Disease
(1′S,2′S)-Nicotine-1'-oxide is an alkaloid N-oxide from the leaves, stems and roots of Nicotiana tabacum .

HY-118614

β-Nicotyrine	Drug Metabolite	Neurological Disease
β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .

HY-W002112

(±)-Nornicotine Nornicotine	Endogenous Metabolite Drug Metabolite	Neurological Disease
(±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .

HY-N6085

N-Caffeoylputrescine,(E)-	Others	Others
N-Caffeoylputrescine,(E)- is a caffeic acid amide found in the tobacco plants (Nicotiana tabacum L.) .

HY-121858

Nicotianamine	Angiotensin-converting Enzyme (ACE)	Metabolic Disease
Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is an angiotensin-converting enzyme (ACE) inhibitor with IC₅₀ values of 76 nM and 59 nM for rhACE2 and rhACE, respectively. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants .

HY-N3890

Exoticin	Others	Others
Exoticin is a natural product that can be isolated from the leaves of Nicotiana plumbaginifolia .

HY-N15133

Solanacol (-)-Solanacol	Others	Others
Solanacol ((-)-Solanacol) is a plant hormone that can be isolated from tobacco (Nicotiana tabacum L.). Solanacol is the germination stimulants for parasitic plants .

HY-W014928

Anabasine hydrochloride (S)-Anabasine hydrochloride; (+)-Anabasine hydrochloride	nAChR	Neurological Disease
Anabasine ((S)-Anabasine) hydrochloride is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 µM) .

HY-W002112R

(±)-Nornicotine (Standard)	Endogenous Metabolite Drug Metabolite	Neurological Disease
(±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine. This product is intended for research and analytical applications. (±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .

HY-118614R

β-Nicotyrine (Standard)	Drug Metabolite	Neurological Disease
β-Nicotyrine (Standard) is the analytical standard of β-Nicotyrine. This product is intended for research and analytical applications. β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .

HY-N15360

Isophytyl acetate	Drug Derivative	Infection
Isophytyl acetate is an organic compound found in Nicotiana plumbaginifolia stems. Isophytyl acetate is promising for research of herbicides .

HY-N10425

2-Hydroxyalbrassitriol	Cholinesterase (ChE)	Neurological Disease
2-Hydroxyalbrassitriol (Compound 6) is an AChE inhibitor with an IC₅₀ of 35.97 μM .

HY-W653822

(2'S)-Nicotine 1-oxide (2S)-Nicotine 1-N-oxide	Drug Metabolite	Others
(2'S)-Nicotine 1-oxide ((2S)-Nicotine 1-N-oxide) is an alkaloid N-oxide, which is found in leaves, stems and roots of Nicotiana tabacum .

HY-162417

PPO-IN-12	Herbicide	Others
PPO-IN-12 (Compound E-Ic) an inhibitor for nicotiana tabacum protoporphyrinogen IX oxidase (NtPPO), with the K_i of 3 nM. Antibacterial agent 208 exhibits a board herbicide spectrum, with good inhibitory activity against broadleaf weeds .

HY-159488

PPO-IN-14	Protoporphyrinogen IX oxidase	Others
PPO-IN-14 (compound B11) is a Nicotiana tobacco Protoporphyrinogen oxidase (NtPPO) inhibitor, with a K_i value of 9.05 nM. PPO-IN-14 (compound B11) could help control weeds in agricultural production .

HY-173015

PPO-IN-16	Herbicide Protoporphyrinogen IX oxidase	Others
PPO-IN-16 (Compound D5) is a PPO inhibitor and herbicide with a K_i of 33.7 nM against Nicotiana tabacum PPO (NtPPO). PPO-IN-16 has a broad herbicidal spectrum and exhibits good safety on crops such as wheat, rice, and peanut .

HY-N7400

Phaseoloidin	Complement System	Others
Phaseoloidin is a homogentisic acid glucoside from Nicotiana attenuata trichomes and contributes to the plant's resistance against lepidopteran herbivores. Phaseoloidin reduces larval growth of the specialist larvae Manduca sexta and the generalist larvae Spodoptera littoralis . Phaseoloidin has anti-complement activitie .

HY-164510

N-Formyldemecolcine	Cytochrome P450	Others
N-Formyldemecolcine is a colchicine precursor that contains the characteristic tropolone ring and pharmacophore of colchicine. N-Formyldemecolcine can be synthesized de novo by genetically engineering transgenic Nicotiana benthamiana and atypical cytochrome P450s that catalyze the production of colchicine's unique carbon scaffold .

HY-N6740R

Beta-Zearalanol (Standard)	Apoptosis	Metabolic Disease
(±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine. This product is intended for research and analytical applications. (±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .

HY-B1532

Anabasine (S)-Anabasine; (+)-Anabasine	nAChR	Neurological Disease
Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical?pesticide?nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 μM) .

HY-N8459

α-Cembrenediol α-CBD	EBV	Cancer
α-Cembrenediol is a potent inhibitor of EBV.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity .

HY-173058

NtPPO-IN-1	Herbicide Protoporphyrinogen IX oxidase	Others
NtPPO-IN-1 (Compound A4) is the inhibitor for Nicotiana tabacum PPO (NtPPO) with a K_i of 9.05 nM. NtPPO-IN-1 exhibits herbicidal activity against Setaria viridis, Echinochloa crus-galli, Digitaria sanguinalis, Amaranthus retroflexus, Abutilon theophrasti and Portulaca oleracea, and exhibits 30-50% injury to corn and rice (150 g a.i./ha) .

HY-163570

PPO-IN-11	Protoporphyrinogen IX oxidase	Others
PPO-IN-11 (Compound 10bh) is an inhibitor for protoporphyrinogen IX oxidase (PPO), that inhibits nicotiana tabacum PPO (NtPPO) with K_i of 0.0603 μM. PPO-IN-11 exhibits herbicidal activities against dicot weeds Leaf mustard, Chickweed, Chenopodium serotinum and monocot weeds Alopecurus aequalis, Poa annua, and Polypogon fugax with a dose of 150 g a.i./ha .

HY-B1532R

Anabasine (Standard)	nAChR	Neurological Disease
Anabasine (Standard) is the analytical standard of Anabasine. This product is intended for research and analytical applications. Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 μM) .

HY-172151

PPO-IN-17	Herbicide Protoporphyrinogen IX oxidase	Others
PPO-IN-17 (Compound 6R) is the inhibitor protoporphyrinogen IX oxidase (PPO) that inhibits Nicotiana tobacco PPO (NtPPO) with K_i of 30.34 nM. PPO-IN-17 exhibits herbicidal activity that inhibits barnyardgrass (E. crus-galli), foxtail grass (D. sanguinalis), alfalfa (M. sativa) and Canada cocklebur (C. canadensis) (>95% inhibition rate at a concentration of 37.5 g/hm ²). PPO-IN-17 exhibits no toxicity on rice (at a concentration of 75 g/hm ²) or on honeybees (at a concentration of 6400 mg/kg) .

(1′S,2′S)-Nicotine-1'-oxide	Natural Products Nicotiana tabacum L. Source classification Plants Solanaceae	Others
(1′S,2′S)-Nicotine-1'-oxide is an alkaloid N-oxide from the leaves, stems and roots of Nicotiana tabacum .

(±)-Nornicotine Nornicotine	Structural Classification Alkaloids Pyrrole Alkaloids Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Endogenous Metabolite Drug Metabolite
(±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .

N-Caffeoylputrescine,(E)-	other families Classification of Application Fields Nicotiana tabacum L. Simple Phenylpropanols Source classification Other Diseases Phenols Polyphenols Phenylpropanoids Plants Solanaceae Disease Research Fields	Others
N-Caffeoylputrescine,(E)- is a caffeic acid amide found in the tobacco plants (Nicotiana tabacum L.) .

Phaseoloidin	Structural Classification Monophenols other families Classification of Application Fields Source classification Other Diseases Phenols Plants Disease Research Fields	Complement System
Phaseoloidin is a homogentisic acid glucoside from Nicotiana attenuata trichomes and contributes to the plant's resistance against lepidopteran herbivores. Phaseoloidin reduces larval growth of the specialist larvae Manduca sexta and the generalist larvae Spodoptera littoralis . Phaseoloidin has anti-complement activitie .

Nicotianamine	Structural Classification Nicotiana tabacum L. Ketones, Aldehydes, Acids Source classification Solanaceae Plants	Angiotensin-converting Enzyme (ACE)
Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is an angiotensin-converting enzyme (ACE) inhibitor with IC₅₀ values of 76 nM and 59 nM for rhACE2 and rhACE, respectively. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants .

Exoticin	Flavonols Flavonoids Classification of Application Fields Nicotiana tabacum L. Source classification Other Diseases Plants Solanaceae Disease Research Fields	Others
Exoticin is a natural product that can be isolated from the leaves of Nicotiana plumbaginifolia .

Solanacol (-)-Solanacol	Structural Classification Natural Products Source classification Solanum lycopersicum L. Solanaceae Plants	Others
Solanacol ((-)-Solanacol) is a plant hormone that can be isolated from tobacco (Nicotiana tabacum L.). Solanacol is the germination stimulants for parasitic plants .

(±)-Nornicotine (Standard)	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Endogenous Metabolite Drug Metabolite
(±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine. This product is intended for research and analytical applications. (±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .

Isophytyl acetate	Structural Classification Natural Products Nicotiana plumbaginifolia Viv. Source classification Solanaceae Plants	Drug Derivative
Isophytyl acetate is an organic compound found in Nicotiana plumbaginifolia stems. Isophytyl acetate is promising for research of herbicides .

2-Hydroxyalbrassitriol	Microorganisms Terpenoids Sesquiterpenes Source classification	Cholinesterase (ChE)
2-Hydroxyalbrassitriol (Compound 6) is an AChE inhibitor with an IC₅₀ of 35.97 μM .

Beta-Zearalanol (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Phenols Polyphenols Antibacterial Disease Research	Apoptosis
(±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine. This product is intended for research and analytical applications. (±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .

Anabasine (S)-Anabasine; (+)-Anabasine	Alkaloids Piperidine Alkaloids Structural Classification Nicotiana tabacum L. Source classification Pyridine Alkaloids Solanaceae Plants	nAChR
Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical?pesticide?nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 μM) .

α-Cembrenediol α-CBD	Structural Classification Natural Products Nicotiana tabacum L. Source classification Plants Solanaceae	EBV
α-Cembrenediol is a potent inhibitor of EBV.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity .

Anabasine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Nicotiana tabacum L. Source classification Pyridine Alkaloids Solanaceae Plants	nAChR
Anabasine (Standard) is the analytical standard of Anabasine. This product is intended for research and analytical applications. Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 μM) .

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Inhibitors & Agonists

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