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Nox2/NADPH oxidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NADPH Oxidase (9) Adrenergic Receptor (2) Apoptosis (1) Isotope-Labeled Compounds (1) Reactive Oxygen Species (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds

Antibodies

Targets Recommended: NADPH Oxidase Xanthine Oxidase Monoamine Oxidase Protoporphyrinogen IX oxidase VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18950

GSK2795039 Maximum Cited Publications 57 Publications Verification	NADPH Oxidase Reactive Oxygen Species Apoptosis	Cancer
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC₅₀ of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption . GSK2795039 reduces apoptosis .

HY-152026

NADPH oxidase-IN-1	NADPH Oxidase	Neurological Disease
NADPH oxidase-IN-1 is an orally active **NADPH oxidase** (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits *Nox2* and *Nox4* with IC₅₀s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .

HY-119576

Phox-I2	NADPH Oxidase Reactive Oxygen Species	Inflammation/Immunology
Phox-I2 is a selective inhibitor of p67 ^phox-Rac1 interaction, binds to p67 ^phox with high affinity with a K_d of ~150 nM. Phox-I2 is a **NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS)** production .

HY-120801

APX-115 1 Publications Verification Ewha-18278	NADPH Oxidase	Metabolic Disease Inflammation/Immunology
APX-115 (Ewha-18278) is a potent, orally active pan **NADPH oxidase (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4**, respectively. APX-115 effectively prevents kidney injury .

HY-120801A

APX-115 free base 1 Publications Verification Ewha-18278 free base; Isuzinaxib free base	NADPH Oxidase	Inflammation/Immunology Endocrinology
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan **NADPH oxidase (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4**, respectively. APX-115 free base effectively prevents kidney injury .

HY-160524

NOX2-IN-3	NADPH Oxidase	Cancer
NOX2-IN-3 (compound 3) is an inhibitor of *NOX2* (NADPH Oxidase 2). NOX2-IN-3 sensitizes tumor cells to MRTX1133 (HY-134813) .

HY-B0203B

(Rac)-Nebivolol (Rac)-R 065824	Adrenergic Receptor NADPH Oxidase	Cardiovascular Disease
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

HY-B0203BS2

(Rac)-Nebivolol-d2,15N (Rac)-R 065824-d₂,¹⁵N	NADPH Oxidase Adrenergic Receptor Isotope-Labeled Compounds	Cardiovascular Disease
(Rac)-Nebivolol-d₂, ¹⁵N is ¹⁵N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

HY-P1435A

NoxA1ds TFA	NADPH Oxidase	Cancer
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

Cat. No.	Product Name	Target	Research Area

HY-P1435A

NoxA1ds TFA	NADPH Oxidase	Cancer
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

Cat. No.	Product Name	Chemical Structure

HY-B0203BS2

(Rac)-Nebivolol-d2,15N
(Rac)-Nebivolol-d₂, ¹⁵N is ¹⁵N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

(Rac)-Nebivolol-d2,15N

(Rac)-Nebivolol-d₂, ¹⁵N is ¹⁵N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81195

	NOX2 Antibody AMCBX2; CGD; CGD91-phox; CY24B_HUMAN; CYBB; Cytochrome b 245, beta polypeptide; Cytochrome b(558) beta chain; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome; P91 PHOX; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	NOX2 Antibody is an unconjugated, approximately 65 kDa, rabbit-derived, anti-NOX2 polyclonal antibody. NOX2 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow, horse, rabbit background without labeling.

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