P60

By Targets:	Antibiotic (1) Apoptosis (2) Autophagy (2) Bacterial (1) EGFR (2) Endogenous Metabolite (1) Ligands for Target Protein for PROTAC (1) Phosphodiesterase (PDE) (2) PROTAC Linkers (1) PROTACs (1) Src (2)
By Research Areas:	Cancer (6) Infection (2)
Click Chemistry:	Azide (1) Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108486

Herbimycin A	Bacterial Antibiotic	Infection
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-16558

Butein 4 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-P10296

p60 (217–225)	Endogenous Metabolite	Infection
p60 (217–225) is the subdominant epitope of Listeria monocytogenes, which combines with H-2K ^d MHC class I molecules .

HY-162943

P60-L3-VHL	PROTACs	Cancer
P60-L3-VHL is a PROTAC-class Foxp3 degrader. P60-L3-VHL reduced cell differentiation and Foxp3 expression in activated Treg cells in vitro and had anti-tumor activity (Blue: E3 ligase ligand (HY-162945); Pink: target protein ligand (HY-162946); Black: linker (HY-162947)) .

HY-P3743

p60c-src Substrate	Src Others	Others
p60c-src Substrate is an efficient and specific substrate for *p60c-src* protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

HY-P3773

p60c-src substrate II	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

HY-162946

Alkyne-P60	Ligands for Target Protein for PROTAC	Cancer
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943).

HY-162947

2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid	PROTAC Linkers	Cancer
2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid is a PROTACT linker and can be used for synthesis of P60-L3-VHL (HY-162943). 2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-16558R

Butein (Standard)	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

Cat. No.	Product Name	Target	Research Area

HY-P10296

p60 (217–225)	Endogenous Metabolite	Infection
p60 (217–225) is the subdominant epitope of Listeria monocytogenes, which combines with H-2K ^d MHC class I molecules .

HY-P2372

P60v-src(137-157)	Peptides	Others
P60v-src(137-157) is a synthetic peptide that inhibits the tyrosine kinase activity of p60 ^v-src (IC₅₀: 7.5 μM) .

HY-P3743

p60c-src Substrate	Src Peptides	Others
p60c-src Substrate is an efficient and specific substrate for *p60c-src* protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

HY-P3771

p60c-src substrate II, phosphorylated	Peptides	Others
p60c-src substrate II, phosphorylated is a pentapeptide. p60c-src substrate II, phosphorylated is a p60c-src substrate II phosphorylated polypeptide. Protein phosphorylation is an important post-translationmodification of protein that is indispensible in biological regulations .

HY-P3773

p60c-src substrate II	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

HY-162946

Alkyne-P60	Ligands for Target Protein for PROTAC	Cancer
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108486

Herbimycin A	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-16558

Butein 4 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	Structural Classification Chalcones Flavonoids other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-16558R

Butein (Standard)	Structural Classification Chalcones Flavonoids other families Source classification Phenols Polyphenols Plants	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

Species:	Human (6) Mouse (4) Rat (2) Cynomolgus (1)
Tag:	His (8) Tag Free (3) GST (2) Flag (1) Fc (2)
Source:	HEK293 (5) Sf9 insect cells (2) CHO (1) Sf9 insect cells (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73422

	Src Protein, Human (sf9, His-GST) Proto-oncogene tyrosine-protein kinase Src; Src; P60-Src; SRC1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His-GST) is the recombinant human-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Src Protein, Human (sf9, His-GST) is 536 a.a., with molecular weight of ~81 kDa.

HY-P73423

	Src Protein, Mouse (sf9, His-GST) Proto-oncogene tyrosine-protein kinase Src; Src; P60-Src; SRC1	Mouse	Sf9 insect cells
	Src, a non-receptor protein tyrosine kinase, displays a unique ability to phosphorylate synaptophysin with high affinity.Src Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701692

	HCK Protein, Human (Sf9, His) HCK; Tyrosine-protein kinase HCK; Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/P60-HCK; p59Hck; p61Hck	Human	Sf9 insect cells
	The HCK protein is a hematopoietic cell-dominated non-receptor tyrosine protein kinase that is critical for innate immune responses in neutrophils, monocytes, macrophages, and mast cells. HCK Protein, Human (Sf9, His) is the recombinant human-derived HCK protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of HCK Protein, Human (Sf9, His) is 446 a.a., .

HY-P74504

	TNFRSF1A Protein, Rat (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, His) is expressed by HEK293 and has a transmembrane region (M1-A211) with a His tag at the C-terminus.

HY-P7305

	TNFRSF1A Protein, Human (CHO) rHuTNFRI; TNFRSF1A; TNFAR; CD120a	Human	CHO
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Human (CHO) is expressed by CHO and has a transmembrane region (D41-N201) .

HY-P700838

	TNFRSF1A Protein, Cynomolgus (HEK293, His) TNF-R1; TNF-RI; FPF; TBP1; TNF-R55; TNFAR; TNFR60; p55; P60; MS5; p55-R; TNFR1-d2	Cynomolgus	HEK293
	TNFRSF1A Protein exhibits a deficiency in conserved residue(s) crucial for feature annotation propagation. TNFRSF1A Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TNFRSF1A protein, expressed by HEK293 , with C-His labeled tag. The total length of TNFRSF1A Protein, Cynomolgus (HEK293, His) is 182 a.a., with molecular weight of 32-42 kDa.

HY-P702724

	Src Protein, Human (sf9, His, Flag) Proto-oncogene tyrosine-protein kinase Src; Src; P60-Src; SRC1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His, Flag) is the recombinant human-derived Src, expressed by Sf9 insect cells , with His, Flag labeled tag. ,

HY-P701321

	Src Protein, Human (His) Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pP60c-src (P60-Src); SRC1	Human	E. coli
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. SRC Protein, Human (His) is the recombinant human-derived SRC protein, expressed by E. coli , with N-10*His labeled tag. The total length of SRC Protein, Human (His) is 535 a.a., with molecular weight of 64.2 kDa.

HY-P701691

	HCK Protein, Human (Q523E, Q524E, Q525I, Sf9) HCK; Tyrosine-protein kinase HCK; Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/P60-HCK; p59Hck; p61Hck	Human	Sf9 insect cells
	The HCK protein is a hematopoietic cell-dominated non-receptor tyrosine protein kinase that is critical for innate immune responses in neutrophils, monocytes, macrophages, and mast cells. HCK Protein, Human (Q523E, Q524E, Q525I, Sf9) is the recombinant human-derived HCK protein, expressed by Sf9 insect cells , with tag free.

HY-P74505

	TNFRSF1A Protein, Rat (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, Fc) is expressed by HEK293 and has a transmembrane region with a Fc tag at the C-terminus.

HY-P72443

	TNF RI/TNFRSF1A Protein, Mouse Tumor necrosis factor receptor superfamily member 1A; TNF-R1; CD120a; Tnfrsf1a	Mouse	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse is expressed by E. coli and has a transmembrane region (I22-A212).

HY-P73449

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region with a Fc tag at the C-terminus.

HY-P73450

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region with a His tag at the C-terminus.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82335

	STIP1 Antibody (YA2080) Hop; P60; STI1; STI1L; STIP1; Stress induced phosphoprotein 1	WB, IHC-P, IP	Human, Mouse, Rat
	STIP1 Antibody (YA2080) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2080), targeting STIP1, with a predicted molecular weight of 63 kDa (observed band size: 63 kDa). STIP1 Antibody (YA2080) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P80899

	SQSTM1/p62 Antibody (YA062) P60; p62; A170; DMRV; OSIL; PDB3; ZIP3; p62B; NADGP; FTDALS3	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
	SQSTM1/p62 Antibody (YA062) is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to SQSTM1/p62. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse.

HY-P80711

	Hsp60 Antibody (YA730) HSPD1; HSP60; 60 kDa heat shock protein; mitochondrial; 60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; HsP60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein	WB, ICC/IF, IP	Human, Mouse, Rat
	Hsp60 Antibody (YA730) is a non-conjugated and Mouse origined monoclonal antibody about 61 kDa, targeting to Hsp60 (6C8). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81766

	p60 Katanin Antibody (YA1511) P60 katanin; Katanin P60 subunit A1	WB	Human
	p60 Katanin Antibody (YA1511) is a biotin-conjugated non-conjugated IgG antibody, targeting p60 Katanin, with a predicted molecular weight of 56 kDa (observed band size: 56 kDa). p60 Katanin Antibody (YA1511) can be used for WB experiment in human background.

HY-P82254

	p60 CAF1 Antibody (YA1999) CAF 1A; CAF IP60; CAF-1; CAF1; CAF1A; CAF1P60; CHAF1B; MPHOSPH7; MPP7	WB, IHC-P, ICC/IF, IP, FC	Human
	p60 CAF1 Antibody (YA1999) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1999), targeting p60 CAF1, with a predicted molecular weight of 61 kDa (observed band size: 70 kDa). p60 CAF1 Antibody (YA1999) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human background.

HY-P82911

	Phospho-Src (Tyr530) Antibody (YA2656) SRC; SRC1; Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pP60c-src; P60-Src	WB, IP	Rat
	Phospho-Src (Tyr530) Antibody (YA2656) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2656), targeting Phospho-Src (Tyr530), with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). Phospho-Src (Tyr530) Antibody (YA2656) can be used for WB, IP experiment in rat background.

HY-P83218

	Tyrosine Protein Kinase HCK Antibody (YA2963) HCK; Tyrosine-protein kinase HCK; Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/P60-HCK; p59Hck; p61Hck	WB, ICC/IF, IP	Human
	Tyrosine Protein Kinase HCK Antibody (YA2963) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2963), targeting Tyrosine Protein Kinase HCK, with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). Tyrosine Protein Kinase HCK Antibody (YA2963) can be used for WB, ICC/IF, IP experiment in human background.

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Cat. No.	Product Name		Classification

HY-162946

Alkyne-P60		Alkynes
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943).

HY-162947

2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid		Azide
2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid is a PROTACT linker and can be used for synthesis of P60-L3-VHL (HY-162943). 2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

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