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Results for "

PCLAF

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Recombinant Proteins

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149428
    AD4
    1 Publications Verification

    		 PROTACs Cancer
    AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .
    AD4
  • HY-162393
    XL44

    		Apoptosis Cancer
    XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13 Pru and ubiquitin-independent loss of select KEN box containing proteins .
    XL44
  • HY-RS10154
    PCLAF Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PCLAF Human Pre-designed siRNA Set A contains three designed siRNAs for PCLAF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PCLAF Human Pre-designed siRNA Set A
    PCLAF Human Pre-designed siRNA Set A

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