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PDK3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Bacterial (1) HSP (1) Parasite (1) PDHK (3) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

VER-246608 2 Publications Verification	PDHK	Cancer
VER-246608 is a potent and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) with IC₅₀s of 35 nM, 40 nM, 84 nM, and 91 nM for *PDK-1, PDK-3, PDK-2, and PDK-4*, respectively.

JX06 1 Publications Verification	PDHK Apoptosis	Cancer
JX06 is a potent, selective and covalent inhibitor of *PDK. JX06 inhibits PDK1, PDK2* and *PDK3* with IC₅₀s of 49 nM, 101 nM, and 313 nM, respectively. JX06 inhibits PDK1 activity via covalently binding to a cysteine residue in an irreversible manner. JX06 shows significant antitumor activity .

Radicicol 3 Publications Verification Monorden	HSP Bacterial Antibiotic Parasite	Infection
Radicicol is an inhibitor of Hsp90 with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on *PDK* with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM ^[3].

PS10 2 Publications Verification	PDHK	Inflammation/Immunology
PS10 is a novel, potent and ATP-competitive pan-PDK* inhibitor,* inhibits all PDK isoforms with IC₅₀ of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (K_d= 239 nM) than for Hsp90 (K_d= 47 μM) . PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy ^[2].PDK: pyruvate dehydrogenase kinase

PDK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PDK3 Human Pre-designed siRNA Set A contains three designed siRNAs for PDK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PDK3 Human Pre-designed siRNA Set A PDK3 Human Pre-designed siRNA Set A

Radicicol 3 Publications Verification Monorden	Structural Classification Antifungal Classification of Application Fields Marine natural products Source classification Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Marine microorganism Disease Research Fields	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of Hsp90 with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on *PDK* with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM ^[3].

Cat. No.	Compare	Product Name	Species	Source

	PDK3 Protein, Mouse (His) PDK3; Pyruvate dehydrogenase kinase isoform 3	Mouse	E. coli
	PDK3 is a metabolic regulator that inhibits pyruvate dehydrogenase through PDHA1 phosphorylation to fine-tune glucose metabolism and affect aerobic respiration. Phosphorylation of PDHA2 adds another layer of control. PDK3 Protein, Mouse (His) is the recombinant mouse-derived PDK3 protein, expressed by E. coli , with N-His labeled tag.

	PDK3 Protein, Human (Inactive, Sf9, His, GST) PDHK3	Human	Sf9 insect cells
	PDK3 Protein, Human (Inactive, Sf9, His, GST) is the recombinant human-derived PDK3, expressed by Sf9 insect cells , with His, GST labeled tag. ,

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PDK3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PDK3 Human Pre-designed siRNA Set A contains three designed siRNAs for PDK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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