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PI3Kδ-IN-21

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158688
    PI3Kδ-IN-21

    		PI3K Inflammation/Immunology
    PI3Kδ-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases δ (PI3Kδ), with an IC50 of 13.6 nM. PI3Kδ-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kδ-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model .
    PI3Kδ-IN-21

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