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Results for "

PMI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) Endogenous Metabolite (1) Mitophagy (1) p62 (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Screening Libraries

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115576

P62-mediated mitophagy inducer 4 Publications Verification PMI	p62 Mitophagy Autophagy	Neurological Disease Cancer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential .

HY-124890

Thr101	Others	Metabolic Disease
Thr101 is an inhibitor (IC₅₀=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .

HY-138802

ML089 1 Publications Verification	Others	Metabolic Disease
ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC₅₀ of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia .

HY-RS10764

PMIS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PMIS2 Human Pre-designed siRNA Set A contains three designed siRNAs for PMIS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PMIS2 Human Pre-designed siRNA Set A PMIS2 Human Pre-designed siRNA Set A

HY-P2799H

Creatine kinase-MB, Human heart CK-MB, Human heart	Endogenous Metabolite	Cardiovascular Disease
Creatine kinase-MB (CK-MB), Human heart is a cardiac biomarker that can be used for early-phase risk detection of periprocedural myocardial infarction (PMI) after coronary artery bypass grafting (CABG) .

Cat. No.	Product Name

HY-L903

3D Diverse Fragment Library	5,400 compounds
Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function. 3-dimensionality (3D) diversity is pivotal because the molecular shape is one of the most important factors in molecular recognition by a biomolecule. There is a developing appreciation that 3D fragments could offer opportunities that are not provided by 2D fragments. MCE 3D Diverse Fragment Library consists of 5,400 non-flat fragment-like molecules (average Fsp3 value 0.58). More than 4,700 fragment compounds contain at least one chiral center in the structure. The key concepts that underlie the library design were 3D shape, structural diversity, reactive functionality and fragment-like. This 3D Diverse Fragment Library brings higher fragment hit optimization and increases the likelihood to find innovative hits in FBDD.

3D Diverse Fragment Library

5,400 compounds

Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function. 3-dimensionality (3D) diversity is pivotal because the molecular shape is one of the most important factors in molecular recognition by a biomolecule. There is a developing appreciation that 3D fragments could offer opportunities that are not provided by 2D fragments.

MCE 3D Diverse Fragment Library consists of 5,400 non-flat fragment-like molecules (average Fsp3 value 0.58). More than 4,700 fragment compounds contain at least one chiral center in the structure. The key concepts that underlie the library design were 3D shape, structural diversity, reactive functionality and fragment-like. This 3D Diverse Fragment Library brings higher fragment hit optimization and increases the likelihood to find innovative hits in FBDD.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81340

	Mannose Phosphate Isomerase Antibody (YA1085) PMI; PMI1; CDG1B	WB, ICC/IF	Human, Rat
	Mannose Phosphate Isomerase Antibody (YA1085) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1085), targeting Mannose Phosphate Isomerase, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). Mannose Phosphate Isomerase Antibody (YA1085) can be used for WB, ICC/IF experiment in human, rat background.

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PMIS2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PMIS2 Human Pre-designed siRNA Set A contains three designed siRNAs for PMIS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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