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Results for "

PON1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

3

Natural
Products

1

Isotope-Labeled Compounds

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0815S
    Chlorpyrifos-d10

    		Cholinesterase (ChE) Neurological Disease
    Chlorpyrifos-d10 is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.
    Chlorpyrifos-d10
  • HY-W015892
    γ-Hexalactone

    γ-Caprolactone

    		 Endogenous Metabolite Others
    γ-Hexalactone is a gamma-lactone found in ripe fruits. γ-Hexalactone induces DNA damage and acts a substrate of paraoxonase 1 (PON1) [1] .
    γ-Hexalactone
  • HY-W017445
    Homogentisic acid lactone

    		Fungal Infection
    Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity [1] .
    Homogentisic acid lactone
  • HY-143239
    PPARα/γ agonist 1

    		PPAR Metabolic Disease
    PPARα/γ agonist 1 (compound 5b) is a potent and dual PPARα/γ partial agonist with EC50 values of 28 nM and 69 nM for PPARα and PPARγ, respectively. PPARα/γ agonist 1 is a promising prototype for dyslipidemia and diabetes research [1].
    PPARα/γ agonist 1
  • HY-RS10872
    PON1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PON1 Human Pre-designed siRNA Set A contains three designed siRNAs for PON1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PON1 Human Pre-designed siRNA Set A
    PON1 Human Pre-designed siRNA Set A
  • HY-146058
    NF-κB/PON1-IN-1

    		NF-κB Reactive Oxygen Species Cancer
    NF-κB/PON1-IN-1 (Compound 16) is a NF-κB/PON1 pathway inhibitor. NF-κB/PON1-IN-1 has antioxidant (IC50 = 45.76 µM) and hepatoprotective activities [1].
    NF-κB/PON1-IN-1
  • HY-130220
    (±)5-HETE lactone

    		Drug Isomer Inflammation/Immunology
    (±)5-HETE lactone is the racemate of 5-HETE lactone. 5-HETE lactone is a metabolite generated by a series of enzymatic reactions of arachidonic acid, and is also a substrate of paraoxonase-1 (PON1). 5-HETE lactone can be used in the study of B cell activation [1] .
    (±)5-HETE lactone
  • HY-W015892R
    γ-Hexalactone (Standard)

    		Endogenous Metabolite Others
    γ-Hexalactone (Standard) is the analytical standard of γ-Hexalactone. This product is intended for research and analytical applications. γ-Hexalactone is a gamma-lactone found in ripe fruits. γ-Hexalactone induces DNA damage and acts a substrate of paraoxonase 1 (PON1) [1] .
    γ-Hexalactone (Standard)

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