Chlorpyrifos-d₁₀

Name: Chlorpyrifos-d 10
Brand: MedChemExpress
SKU: HY-B0815S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0815S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

For research use only. We do not sell to patients.

Chlorpyrifos-d<sub>10</sub> Chemical Structure

Chlorpyrifos-d₁₀ Chemical Structure

CAS No. : 285138-81-0

Size	Price	Stock	Quantity
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Chlorpyrifos-d₁₀:

Chlorpyrifos Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

360.65

Formula

C₉HD₁₀Cl₃NO₃PS

CAS No.

285138-81-0

Unlabeled CAS

2921-88-2

Appearance

Solid

Color

White to off-white

SMILES

S=P(OC([2H])([2H])C([2H])([2H])[2H])(OC1=NC(Cl)=C(Cl)C=C1Cl)OC([2H])([2H])C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (277.28 mM; Need ultrasonic)

DMSO : 50 mg/mL (138.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7728 mL	13.8639 mL	27.7277 mL
5 mM	0.5546 mL	2.7728 mL	5.5455 mL
10 mM	0.2773 mL	1.3864 mL	2.7728 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (278 KB) SDS (564 KB)

COA (258 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO / H₂O / H₂O	1 mM	2.7728 mL	13.8639 mL	27.7277 mL	69.3193 mL
	5 mM	0.5546 mL	2.7728 mL	5.5455 mL	13.8639 mL
	10 mM	0.2773 mL	1.3864 mL	2.7728 mL	6.9319 mL
	15 mM	0.1849 mL	0.9243 mL	1.8485 mL	4.6213 mL
	20 mM	0.1386 mL	0.6932 mL	1.3864 mL	3.4660 mL
	25 mM	0.1109 mL	0.5546 mL	1.1091 mL	2.7728 mL
	30 mM	0.0924 mL	0.4621 mL	0.9243 mL	2.3106 mL
	40 mM	0.0693 mL	0.3466 mL	0.6932 mL	1.7330 mL
	50 mM	0.0555 mL	0.2773 mL	0.5546 mL	1.3864 mL
	60 mM	0.0462 mL	0.2311 mL	0.4621 mL	1.1553 mL
	80 mM	0.0347 mL	0.1733 mL	0.3466 mL	0.8665 mL
	100 mM	0.0277 mL	0.1386 mL	0.2773 mL	0.6932 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.