PROS1

By Targets:	Apoptosis (1) DNA Stain (1) Fluorescent Dye (1) Macrophage migration inhibitory factor (MIF) (1) SARS-CoV (7) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0917

TO-PRO 1	DNA Stain	Cancer
TO-PRO 1 is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm). TO-PRO 1 can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. TO-PRO 1 is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. TO-PRO 1 can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. TO-PRO 1 can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies ^[1] .

HY-D0918

YO-PRO-1	Fluorescent Dye	Others
YO-PRO-1 is a non-cell-membrane-penetrating green fluorescent dye. YO-PRO-1 cannot penetrate normal cell membranes but can penetrate the membranes of apoptotic and necrotic cells. YO-PRO-1 has a high affinity for DNA. When it is not bound to DNA, it emits almost no fluorescence, and when it binds to DNA, it can emit green fluorescence (Ex/Em: 488/530±30 nM). YO-PRO-1 is often used together with Propidium Iodide (HY-D0815) to analyze and identify apoptotic and necrotic cells ^[1] .

HY-P4388A

Z-Arg-Leu-Arg-Gly-Gly-AMC acetate	SARS-CoV	Infection
Z-Arg-Leu-Arg-Gly-Gly-AMC acetate is a peptide substrate for SARS-CoV PL ^pro .

HY-136298A

X77	SARS-CoV	Infection
X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 M ^pro) . X77 binds to SARS-CoV-2 M ^pro with a K_d value of 0.057 μM .

HY-110084

BTZO-1 1 Publications Verification	Macrophage migration inhibitory factor (MIF) Apoptosis	Cardiovascular Disease
BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a K_d value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro ^[1].

HY-RS25327

Pros1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pros1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pros1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pros1 Rat Pre-designed siRNA Set A Pros1 Rat Pre-designed siRNA Set A

HY-RS18835

Pros1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pros1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pros1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pros1 Mouse Pre-designed siRNA Set A Pros1 Mouse Pre-designed siRNA Set A

HY-RS11202

PROS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PROS1 Human Pre-designed siRNA Set A contains three designed siRNAs for PROS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PROS1 Human Pre-designed siRNA Set A PROS1 Human Pre-designed siRNA Set A

HY-P4388

Z-Arg-Leu-Arg-Gly-Gly-AMC	SARS-CoV	Infection
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL ^pro .

HY-154976

SARS-CoV-2-IN-50	SARS-CoV	Infection
SARS-CoV-2-IN-50 (Compound X77C) is a SARS-CoV-2 main protease (M ^Pro) inhibitor.. SARS-CoV-2-IN-50 has a high affinity to the catalytic site of M ^Pro .

HY-149655

D1N8	SARS-CoV	Infection
D1N8 is a potent SARS-CoV-2 3CL ^pro inhibitor with an IC₅₀ and CC₅₀ values of 0.44 μM and >20 μM, respectively. D1N8 has the potential for the research of anti-SARS-CoV-2 agents targeting 3CL ^pro .

HY-136298

(Rac)-X77	SARS-CoV	Infection
(Rac)-X77?is a racemate of X77. X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 M ^pro) . X77 binds to SARS-CoV-2 M ^pro with a K_d value of 0.057 μM .

HY-157145

SARS-CoV-2-IN-69	SARS-CoV	Infection
SARS-CoV-2-IN-69 (Compound 7E) is a non-covalent SARS-CoV-2 inhibitor with an EC₅₀ value of 7.4 μM. SARS-CoV-2-IN-69 is a potent inhibitor of SARS-CoV-2 main protease (M ^pro) and a non-covalent inhibitor of papain (PL ^pro) .

Cat. No.	Product Name	Type

HY-D0917

TO-PRO 1	DNA Stain
TO-PRO 1 is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm). TO-PRO 1 can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. TO-PRO 1 is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. TO-PRO 1 can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. TO-PRO 1 can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies ^[1] .

TO-PRO 1

DNA Stain

TO-PRO 1 is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm). TO-PRO 1 can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. TO-PRO 1 is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. TO-PRO 1 can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. TO-PRO 1 can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies ^[1] .

HY-D0918

YO-PRO-1	Fluorescent Dyes/Probes
YO-PRO-1 is a non-cell-membrane-penetrating green fluorescent dye. YO-PRO-1 cannot penetrate normal cell membranes but can penetrate the membranes of apoptotic and necrotic cells. YO-PRO-1 has a high affinity for DNA. When it is not bound to DNA, it emits almost no fluorescence, and when it binds to DNA, it can emit green fluorescence (Ex/Em: 488/530±30 nM). YO-PRO-1 is often used together with Propidium Iodide (HY-D0815) to analyze and identify apoptotic and necrotic cells ^[1] .

YO-PRO-1

Fluorescent Dyes/Probes

YO-PRO-1 is a non-cell-membrane-penetrating green fluorescent dye. YO-PRO-1 cannot penetrate normal cell membranes but can penetrate the membranes of apoptotic and necrotic cells. YO-PRO-1 has a high affinity for DNA. When it is not bound to DNA, it emits almost no fluorescence, and when it binds to DNA, it can emit green fluorescence (Ex/Em: 488/530±30 nM). YO-PRO-1 is often used together with Propidium Iodide (HY-D0815) to analyze and identify apoptotic and necrotic cells ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P4388A

Z-Arg-Leu-Arg-Gly-Gly-AMC acetate	SARS-CoV	Infection
Z-Arg-Leu-Arg-Gly-Gly-AMC acetate is a peptide substrate for SARS-CoV PL ^pro .

HY-P4388

Z-Arg-Leu-Arg-Gly-Gly-AMC	SARS-CoV	Infection
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL ^pro .

Cat. No.	Product Name

HY-K1092

*YO-PRO-1/PI Apoptosis and Necrosis Detection Kit*
MCE YO-PRO-1/PI Apoptosis and Necrosis Detection Kit is a dual-fluorescence method based on the green fluorescent dye YO-PRO-1 (YP1) and the red fluorescent dye Propidium Iodide (PI) for detecting cell apoptosis and necrosis.

Cat. No.	Compare	Product Name	Species	Source

HY-P74614

	*Protein S/PROS1* Protein, Human (HEK293, His)** Vitamin K-dependent protein S; PROS1; PROS	Human	HEK293
	Protein S/PROS1 Proteinas are potent antagonists of BMP4 and inhibit BMP4 by binding to BMP4 and preventing receptor interaction. This change redirects neural stem cells from gliogenesis to neurogenesis, thereby promoting the differentiation of neurons in the brain. Protein S/PROS1 Protein, Human (HEK293, His) is the recombinant human-derived protein S/PROS1 protein, expressed by HEK293 , with C-His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83174

	Protein S Antibody (YA2919) Preproprotein S; PROS; PROS1; PS21; PS22; PS23; PS24; PS25; PS26; PSA; THPH5; THPH6	WB	Human
	Protein S Antibody (YA2919) is a non-conjugated IgG antibody, targeting Protein S, with a predicted molecular weight of 75 kDa (observed band size: 75 kDa). Protein S Antibody (YA2919) can be used for WB experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS25327

Pros1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pros1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pros1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18835

Pros1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pros1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pros1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11202

PROS1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PROS1 Human Pre-designed siRNA Set A contains three designed siRNAs for PROS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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