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Pathways Recommended: PROTAC
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PROTAC CRBN ligand 2

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103596
    Thalidomide-4-OH

    Cereblon ligand 2; E3 ligase ligand 2

    		 Ligands for E3 Ligase Autophagy Apoptosis Cancer
    Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .
    Thalidomide-4-OH
  • HY-158152
    PROTAC CRBN ligand-2

    		Ligands for E3 Ligase Cancer
    PROTAC CRBN ligand-2 (12) is a Biguanide-PROTAC derivative, with an EC50 of 0.15 mM in KP4 cells. PROTAC CRBN ligand-2 (12) demonstrates the ability to alter levels of mitochondrial proteins, notably complexes I and IV .
    PROTAC CRBN ligand-2
  • HY-168867
    RD-23

    		PROTACs RET Apoptosis Cancer
    RD-23 is an orally active and selective RET PROTAC degrader. RD-23 promotes ubiquitination and degradation of RET G810C mutation, with a DC50 value of 11.7 nM. RD-23 inhibits the activation of downstream Shc signaling and induces Apoptosis. RD-23 can be used for the research of RET-related cancers (Pink: RET ligand-2 (HY-168868); Blue: E3 ligase CRBN ligand; Black: linker) .
    RD-23
  • HY-W674436
    (S)-Thalidomide-4-OH

    		Drug Isomer Cancer
    (S)-Thalidomide-4-OH is the S-isomer of Thalidomide-4-OH (HY-103596). Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .
    (S)-Thalidomide-4-OH

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