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Results for "

PYK2

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Peptides

1

Recombinant Proteins

2

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-401485
    Pyk2-IN-2

    		Pyk2 FAK Cancer
    Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM .
    Pyk2-IN-2
  • HY-18312
    PF-4618433
    2 Publications Verification

    		 Pyk2 Metabolic Disease
    PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration [2].
    PF-4618433
  • HY-10458
    PF-562271 besylate
    Maximum Cited Publications
    20 Publications Verification

    VS-6062 besylate

    		 FAK Pyk2 Cancer
    PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC50 of 1.5 nM and 13 nM, respectively .
    PF-562271 besylate
  • HY-109084
    Conteltinib

    CT-707

    		 FAK Cancer
    Conteltinib (CT-707) is a multi-kinase inhibitor targeting FAK, ALK, and Pyk2. Conteltinib exerts significant inhibitory effect on FAK with an IC50 of 1.6 nM .
    Conteltinib
  • HY-10459
    PF-562271
    Maximum Cited Publications
    20 Publications Verification

    VS-6062

    		 FAK Pyk2 Cancer
    PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively .
    PF-562271
  • HY-10460
    PF-431396
    5+ Cited Publications

    		 Pyk2 FAK Cancer
    PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC50 values of 2 nM and 11 nM, respectively [2] .
    PF-431396
  • HY-15322
    PRT062607
    3 Publications Verification

    P505-15; PRT-2607; BIIB-057

    		 Syk Inflammation/Immunology
    PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.
    PRT062607
  • HY-13203
    NVP-TAE 226
    5+ Cited Publications

    TAE226

    		 FAK Pyk2 IGF-1R Insulin Receptor Apoptosis Endocrinology Cancer
    NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively [2].
    NVP-TAE 226
  • HY-109082
    Cevidoplenib

    SKI-O-703

    		 Syk Inflammation/Immunology
    Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC50s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively [2] .
    Cevidoplenib
  • HY-20403
    PF-562271 hydrochloride

    VS-6062(hydrochloride)

    		 FAK Pyk2 Cancer
    PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively .
    PF-562271 hydrochloride

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