2. Protein Tyrosine Kinase/RTK
  3. FAK
  4. Conteltinib tetrahydrochloride

Conteltinib tetrahydrochloride  (Synonyms: CT-707 tetrahydrochloride)

Cat. No.: HY-109084A
Handling Instructions Technical Support

Conteltinib tetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride salt form of Conteltinib (HY-109084). Conteltinib tetrahydrochloride is the inhibitor for FAK (IC50=1.6 nM), ALK, and Pyk2. Conteltinib tetrahydrochloride exhibits a synergistic anti-tumor efficacy with Cabozantinib (HY-13016).

For research use only. We do not sell to patients.

Conteltinib tetrahydrochloride Chemical Structure

Conteltinib tetrahydrochloride Chemical Structure

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Conteltinib tetrahydrochloride Related Antibodies

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Description

Conteltinib tetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride salt form of Conteltinib (HY-109084). Conteltinib tetrahydrochloride is the inhibitor for FAK (IC50=1.6 nM), ALK, and Pyk2. Conteltinib tetrahydrochloride exhibits a synergistic anti-tumor efficacy with Cabozantinib (HY-13016)[1].

Molecular Weight

781.67

Formula

C32H49Cl4N9O3S
SMILES

O=S(NC(C)C)(C1=C(NC2=NC(NC3=CC=C(N4CCC(CC4)N5CCN(CC5)C)C=C3OC)=NC6=C2CCN6)C=CC=C1)=O.Cl.Cl.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (127.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2793 mL 6.3966 mL 12.7931 mL
5 mM 0.2559 mL 1.2793 mL 2.5586 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2793 mL 6.3966 mL 12.7931 mL 31.9828 mL
5 mM 0.2559 mL 1.2793 mL 2.5586 mL 6.3966 mL
10 mM 0.1279 mL 0.6397 mL 1.2793 mL 3.1983 mL
15 mM 0.0853 mL 0.4264 mL 0.8529 mL 2.1322 mL
20 mM 0.0640 mL 0.3198 mL 0.6397 mL 1.5991 mL
25 mM 0.0512 mL 0.2559 mL 0.5117 mL 1.2793 mL
30 mM 0.0426 mL 0.2132 mL 0.4264 mL 1.0661 mL
40 mM 0.0320 mL 0.1599 mL 0.3198 mL 0.7996 mL
50 mM 0.0256 mL 0.1279 mL 0.2559 mL 0.6397 mL
60 mM 0.0213 mL 0.1066 mL 0.2132 mL 0.5330 mL
80 mM 0.0160 mL 0.0800 mL 0.1599 mL 0.3998 mL
100 mM 0.0128 mL 0.0640 mL 0.1279 mL 0.3198 mL
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Conteltinib tetrahydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Conteltinib tetrahydrochlorideCT-707 tetrahydrochlorideFAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseHepG2Inhibitorinhibitorinhibit

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