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Results for "

Polymerase Theta

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161302
    Polθ/PARP-IN-1

    		Apoptosis DNA/RNA Synthesis PARP Cancer
    Polθ/PARP-IN-1 (compound 25d) is a potent dual DNA polymerase theta (Polθ) and PARP inhibitor with IC50 values of 45.6, 5.4 nM, respectively. Polθ/PARP-IN-1 shows antiproliferative activity. Polθ/PARP-IN-1 induces apoptosis and cell cycle arrest at G2/M phase, causes DNA damage. Polθ/PARP-IN-1 shows anti-tumor activity .
    Polθ/PARP-IN-1
  • HY-141520
    ART558
    Maximum Cited Publications
    19 Publications Verification

    		 DNA/RNA Synthesis Cancer
    ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer .
    ART558
  • HY-139289
    ART812
    1 Publications Verification

    		 DNA/RNA Synthesis Cancer
    ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ) .
    ART812
  • HY-151462
    RP-6685
    1 Publications Verification

    		 DNA/RNA Synthesis Cancer
    RP-6685 is a potent, selective and orally active DNA polymerase theta (Polθ) inhibitor with an IC50 value of 5.8 nM (PicoGreen assay). RP-6685 shows antitumor efficacy in mouse tumor xenograft model . RP-6685 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    RP-6685
  • HY-161430
    RTx-161

    		DNA/RNA Synthesis Apoptosis Cancer
    RTx-161 is an allosteric Polθ polymerase inhibitor with an IC50 value of 4.1 nM. RTx-161 selectively kills HR-deficient cancer cells and suppresses PARP inhibitor (PARPi) resistance in multiple genetic backgrounds, including HR-proficient cells. Additionally, RTx-161 can induce apoptosis .
    RTx-161
  • HY-158346
    Polθ-IN-3

    		DNA/RNA Synthesis Cancer
    Polθ-IN-3 (Compound 113) is an orally active inhibitor of Polymerase Theta (Polθ). Polθ-IN-3 has antitumor activity .
    Polθ-IN-3
  • HY-159078
    PolQi1

    		DNA/RNA Synthesis Cancer
    PolQi1 is a Polϴ (polymerase theta) inhibitor. PolQi1 targets the polymerase domain of the enzyme .
    PolQi1
  • HY-161916
    Polθ-IN-4

    		DNA/RNA Synthesis Cancer
    Polθ-IN-4 (Example 1) is a DNA polymerase theta (Polθ) inhibitor that inhibits Polθ activity by targeting its ATP-dependent helicase domain. Polθ-IN-4 can be utilized in cancer research .
    Polθ-IN-4

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