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RGMA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Small Interfering RNA (siRNA) (1) TGF-beta/Smad (1)
By Research Areas:	Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .

RGMA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RGMA Human Pre-designed siRNA Set A contains three designed siRNAs for RGMA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RGMA Human Pre-designed siRNA Set A RGMA Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .

Unasnemab MT-3921; rH116A3	Inhibitory Antibodies	Neurological Disease
Unasnemab (MT-3921) is a humanised IgG1 monoclonal antibody that binds to repulsive guidance molecule A (RGMa). Unasnemab improves locomotor function and promotes neuroregeneration and can be used for the research of spinal cord injury .

Cat. No.	Compare	Product Name	Species	Source

	RGMA Protein, Human (HEK293, His) Repulsive guidance molecule A; RGM domain family member A; RGMA; RGM	Human	HEK293
	The RGMA protein is a member of the repulsion guidance molecule (RGM) family and plays multiple roles in nervous system development and function. It controls neural tube closure, inhibits neurite growth, inhibits neuronal branching, and regulates the formation of mature synapses. RGMA Protein, Human (HEK293, His) is the recombinant human-derived RGMA protein, expressed by HEK293 , with C-His labeled tag.

	RGMA Protein, Human (HEK293, His-Avi) RGMA; RGM	Human	HEK293
	The RGMA protein is a member of the repulsion guidance molecule (RGM) family and plays multiple roles in nervous system development and function. It controls neural tube closure, inhibits neurite growth, inhibits neuronal branching, and regulates the formation of mature synapses. RGMA Protein, Human (HEK293, His-Avi) is the recombinant human-derived RGMA protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

	RGMA Protein, Human (Biotinylated, HEK293, His-Avi) RGMA; RGM	Human	HEK293
	The RGMA protein is a member of the repulsion guidance molecule (RGM) family and plays multiple roles in nervous system development and function. It controls neural tube closure, inhibits neurite growth, inhibits neuronal branching, and regulates the formation of mature synapses. RGMA Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived RGMA protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

	RGMA Protein, Human (His) Repulsive guidance molecule A; RGM domain family member A; RGM	Human	E. coli
	Repulsive guidance molecule A (RGMA) is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. RGMA regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. RGMA also functions as a bone morphogenetic protein (BMP) coreceptor and may act as a tumor suppressor in some cancers. RGMA Protein, Human (His) is the recombinant human-derived RGMA protein, expressed by E. coli , with N-6*His labeled tag.

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RGMA Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
RGMA Human Pre-designed siRNA Set A contains three designed siRNAs for RGMA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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