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Rho-associated

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROCK (5) Endogenous Metabolite (1) Influenza Virus (1) PKC (1) Ras (1) Tyrosinase (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Inflammation/Immunology (1) Neurological Disease (1)

6

Inhibitors & Agonists

1

Natural
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2

Recombinant Proteins

Targets Recommended: ROCK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Netarsudil hydrochloride AR-13324 hydrochloride	ROCK	Neurological Disease
Netarsudil hydrochloride (AR-13324 hydrochloride) is a Rho-associated protein kinas (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil hydrochloride has effective in intraocular pressure (IOP) reduction .

GSK180736A 5 Publications Verification	ROCK	Cardiovascular Disease
GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC₅₀ of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC₅₀ of 0.77 μM.

Zelasudil RXC007	ROCK	Cancer
Zelasudil (RXC007) is an orally active, highly selective small molecule Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor with anti-fibrotic efficacy. Zelasudil elicits positive immunomodulatory effects in metastatic pancreatic tumors with increase of CD8+ and CD4+ T cell infiltrate into the tumor cortex and reduction in immunosuppressive FOXP3+ regulatory T cells at the tumor border. Zelasudil is promising for research of pancreatic ductal adenocarcinoma .

N-Acetylneuraminic acid 3 Publications Verification NANA; Lactaminic acid	Tyrosinase Ras Influenza Virus Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

WF-536	ROCK	Cancer
WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer .

CMPD101 hydrochloride	PKC ROCK	Cardiovascular Disease
CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC₅₀s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC₅₀s =1.4 μM and 8.1 μM, respectively) .

Cat. No.	Product Name	Category	Target	Chemical Structure

N-Acetylneuraminic acid 3 Publications Verification NANA; Lactaminic acid	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides	Tyrosinase Ras Influenza Virus Endogenous Metabolite
N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

	ROCK1 Protein, Human (Sf9) ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated; coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK	Human	Sf9 insect cells
	The ROCK1 protein is a key kinase that regulates the actin cytoskeleton, cell polarity, smooth muscle contraction, and multiple cellular functions. It controls stress fibers, focal adhesion formation, neurite retraction, and cell motility by phosphorylating substrates such as DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1, and PPP1R12A. ROCK1 Protein, Human (Sf9) is the recombinant human-derived ROCK1 protein, expressed by Sf9 insect cells , with tag free. The total length of ROCK1 Protein, Human (Sf9) is 410 a.a., .

	ROCK1 Protein, Human (Sf9, His) ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated; coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK	Human	Sf9 insect cells
	The ROCK1 protein is a key kinase that regulates the actin cytoskeleton, cell polarity, smooth muscle contraction, and multiple cellular functions. It controls stress fibers, focal adhesion formation, neurite retraction, and cell motility by phosphorylating substrates such as DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1, and PPP1R12A. ROCK1 Protein, Human (Sf9, His) is the recombinant human-derived ROCK1 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of ROCK1 Protein, Human (Sf9, His) is 410 a.a., .

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