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SAL 0010042

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-170431
    SAL-0010042

    		Phosphodiesterase (PDE) Parasite Infection
    SAL-0010042 is the inhibitor for Plasmodium phosphodiesterase β (PDEβ), that inhibits the hydrolysis of cAMP and cGMP (IC50=48.9 nM) in gametocytes, activates PKG, and inhibits the growth and development of Plasmodium (IC50 for 3D7 and Dd2 is 142 nM and 218 nM). SAL-0010042 inhibits hPDE5 and hPDE6 with IC50 of 632 nM and 73 nM .
    SAL-0010042

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