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Results for "

SARS-CoV PLpro inhibitor

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

1

Natural
Products

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168259
    PLpro-IN-8

    		SARS-CoV Infection
    PLpro-IN-8 (compound 1) is a SARS-CoV papain-like protease (PLpro) inhibitor with IC50 values of 5.9 μM and 0.46 μM for SARS-CoV-2 PLpro and SARS -CoV-1 PLpro, respectively. PLpro-IN-8 inhibits Wuhan strain WK-521 of SARS-CoV-2 with an EC50 of 2.7 μM .
    PLpro-IN-8
  • HY-170399
    SARS-CoV-2 PLpro-IN-1

    		SARS-CoV Virus Protease Infection Cancer
    SARS-CoV-2 PLpro-IN-1 (Compound 85) is a non-covalent and competitive inhibitor of SARS-CoV-2 PLpro with an IC50 of 15.06 μM and a Ki of 22.93 μM. SARS-CoV-2 PLpro-IN-1 inhibits the proliferation of Vero cell with an IC50 of 7.47 μM .
    SARS-CoV-2 PLpro-IN-1
  • HY-157144
    SARS-CoV-2-IN-68

    		SARS-CoV Infection
    SARS-CoV-2-IN-68 (compound 6C) is a covalent SARS-CoV-2 PLpro/Mpro inhibitor with potent antiviral activities. SARS-CoV-2-IN-68 binds to Zn-finger domain of PLpro .
    SARS-CoV-2-IN-68
  • HY-159633
    PLpro-IN-5

    		SARS-CoV Infection
    PLpro-IN-5 (compound 21) is a PLPro protease inhibitor with an IC50 value of 91.14 nM. PLpro-IN-5 shows broad-spectrum antivirus, especially for SARS-CoV, MERS-CoV, SARS-CoV-2 .
    PLpro-IN-5
  • HY-168584
    SARS-CoV-2-IN-102

    		SARS-CoV Infection
    SARS-CoV-2-IN-102 (example 58) is a SARS-CoV papain-like protease (PLpro) inhibitor with an IC50 <100 nM .
    SARS-CoV-2-IN-102
  • HY-162790
    SARS-CoV-2-IN-95

    		SARS-CoV Virus Protease Infection
    SARS-CoV-2-IN-95 (Compound 10) is an inhibitor for SARS-CoV-2 PLpro with an IC50 of 0.39 μM. SARS-CoV-2-IN-95 exhibits antiviral activity in mouse SARS-CoV-2-infected model .
    SARS-CoV-2-IN-95
  • HY-155308
    SARS-CoV-2-IN-61

    		SARS-CoV Infection
    SARS-CoV-2-IN-61 (compound 8i) is a SARS CoV-2 PLpro inhibitor with an IC50 of 16 µM. SARS-CoV-2-IN-61 has antiviral activities .
    SARS-CoV-2-IN-61
  • HY-139892
    XR8-69

    		SARS-CoV Infection
    XR8-69 is a SARS-CoV-2 PLpro inhibitor that shows low micromolar antiviral potency in SARS-CoV-2-infected human cells.
    XR8-69
  • HY-128427
    PLpro-IN-1

    		SARS-CoV Infection
    PLpro-IN-1 (Compound 2) is a SARS-CoV PLpro inhibitor (IC50: 8.7 μM). PLpro-IN-1 can be used for antiviral research .
    PLpro-IN-1
  • HY-150789
    SARS-CoV-2-IN-23

    		SARS-CoV Infection
    SARS-CoV-2-IN-23 (compound GRL-0617) is a SARS-COV-2 papain-like protease (PLpro) inhibitor with an IC50 value of 2.3 μM .
    SARS-CoV-2-IN-23
  • HY-161365
    PLpro-IN-2

    		SARS-CoV Infection
    PLpro-IN-2 (Compound 16) is an inhibitor for SARS-CoV-2 papain-like protease (PLpro), with an IC50 of 0.25 μM .
    PLpro-IN-2
  • HY-17542
    PLpro inhibitor
    5+ Cited Publications

    		 SARS-CoV Infection
    PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC50 of 2.6 µM . PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 µM and an EC50 of 21.0 µM .
    PLpro inhibitor
  • HY-W423489
    SARS-CoV-2-IN-76

    S-Adenosyl-DL-homocysteine

    		 SARS-CoV Infection
    SARS-CoV-2-IN-76 (compound 1) is a nsp14-viral cap N7 methyltranferase and PLpro inhibitor of severe acute respiratory syndrome corona virus (SARS-CoV-2) .
    SARS-CoV-2-IN-76
  • HY-164868
    SARS-CoV-2-IN-106

    		SARS-CoV Infection
    SARS-CoV-2-IN-106 (compound 19) is a SARS-CoV-2 papain-like protease inhibitor with the IC50 values of 0.44 μM and 0.18 μM for PLpro enzymatic and viral replication ,respectively .
    SARS-CoV-2-IN-106
  • HY-161729
    PLpro-IN-3

    		SARS-CoV Infection
    PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC50 of 1.0μM. PLpro-IN-3 exhibits antiviral activity against SARS-CoV-2 with a EC50 of 4.3 μM .
    PLpro-IN-3
  • HY-149256
    PLpro/RBD-IN-1

    		SARS-CoV Infection
    PLpro/RBD-IN-1 (compound 5) is a dual SARS-CoV-2 PLpro and spike protein RBD inhibitor with IC50s of 7.197 μM and 8.673 μM, respectively .
    PLpro/RBD-IN-1
  • HY-149940
    SIMR3030

    		SARS-CoV Infection
    SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice .
    SIMR3030
  • HY-117043
    GRL0617
    Maximum Cited Publications
    10 Publications Verification

    		 Deubiquitinase SARS-CoV Infection
    GRL0617 is a selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro), with an IC50 of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC50 of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome .
    GRL0617
  • HY-169092
    PF-07957472

    		SARS-CoV Virus Protease Infection
    PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC50 = 13.9 nM). PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model .
    PF-07957472
  • HY-158751
    Jun9-72-2

    		SARS-CoV Infection
    Jun9-72-2 is a papain (Plpro) inhibitor of SARS-CoV-2 with an IC50 value of 0.67 μM. Jun9-72-2 has antiviral activity .
    Jun9-72-2
  • HY-159655
    PLpro-IN-6

    		SARS-CoV Infection Inflammation/Immunology
    PLpro-IN-6 (compound 6) is a papain-like protease (PLpro) inhibitor, with an IC50 of 0.019 μM for SARS CoV2 PLpro enzyme .
    PLpro-IN-6
  • HY-N1910
    4'-O-Methylbavachalcone
    1 Publications Verification

    		 SARS-CoV Infection
    4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM .
    4'-O-Methylbavachalcone
  • HY-144648
    Mpro/PLpro-IN-1

    		SARS-CoV Infection
    Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of M pro/PL pro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus M pro (IC50 = 1.72 μM) and submicromolar potency versus PL pro (IC50 = 0.67 μM) .
    Mpro/PLpro-IN-1
  • HY-170504
    ZHAWOC25153

    		SARS-CoV Virus Protease Infection
    ZHAWOC25153 (Compound 17o) is a SARS-CoV-2 papain-like cysteine protease (PLpro) inhibitor, with an IC50 of 7 μM. ZHAWOC25153 exhibits antiviral activity and can be used in research within the field of anti-infection .
    ZHAWOC25153

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