SIMR3030

Cat. No.: HY-149940: FAQs
Data Sheet Handling Instructions

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SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC₅₀ value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice.

For research use only. We do not sell to patients.

SIMR3030 Chemical Structure

CAS No. : 2708270-99-7

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Description

IC₅₀ & Target

IC₅₀: 0.0399 µg/mL (SARS-CoV-2 PLpro)^[1]

In Vitro

SIMR3030 (0-100 µg/mL) shows antiviral activity with IC₅₀ values of 12.1, 6.206 μg/mL for SARS-CoV-2 and MERS-CoV, respectively^[1].
SIMR3030 (20 µg/mL; 1, 6, 12 h) decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression levels in Caco-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	Caco-2 cells (SARS-CoV-2 RNA infected)
Concentration:	20 μg/mL
Incubation Time:	1, 6, 12 h
Result:	Decreased SARS-CoV spike and ORF1b mRNA expression levels, reduced the mRNA expression of IFN-α at 1 and 3 h , IL-6 and OAS1 at 1, 3 and 12 h.

In Vivo

SIMR3030 (25, 50, 100 mg/kg; I.p.; daily for 14 days) exhibits a satisfactory safety profile in experimental mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	18-25 g, adult female Balb/c mice^[1]
Dosage:	25, 50, 100 mg/kg
Administration:	I.p.; daily for 14 days
Result:	Showed no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days, no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days.

Molecular Weight

427.54

Formula

C₂₇H₂₉N₃O₂

CAS No.

2708270-99-7

SMILES

[H][C@@]12CC[C@]3(CC4=C(NC5=C4C=C(C=C5)OC)C[C@]3(N1CCC6=C2NC7=CC=CC=C76)[H])OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hersi F, et al. Discovery of novel papain-like protease inhibitors for potential treatment of COVID-19. Eur J Med Chem. 2023 Jun 5;254:115380. [Content Brief]

SIMR3030 Related Classifications

Infection

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIMR30302708270-99-7SIMR 3030SIMR-3030SARS-CoVSARS coronavirusCaco-2 cellsantiviralSARS-CoV spikeORF1bIFN-αIL-6Inhibitorinhibitorinhibit

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