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SK-3-91

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137341
    SK-3-91

    		PROTACs Cancer
    SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases) . SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) TAE648 (HY-169396), the E3 ubiquitin ligase ligand (blue part) Thalidomide-NH-CH2-COOH (HY-131717) and the PROTAC linker (Bromo-PEG1-C2-azide) (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397).
    SK-3-91
  • HY-137340
    WH-10417-099

    		PROTACs Cancer
    WH-10417-099 is a CRBN-type PROTAC multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). WH-10417-099 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) PI3Kγ ligand 1 (HY-168319), the E3 ubiquitin ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547) and the PROTAC linker (black part) Amino-PEG5-C2-acid (HY-115384). The E3 ligase ligand and linker can form a conjugate Pomalidomide 4'-PEG5-acid (HY-131647).
    WH-10417-099
  • HY-169396
    TAE648

    		Ligands for Target Protein for PROTAC Cancer
    TAE648 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC SK-3-91 (HY-137341) .
    TAE648
  • HY-169397
    Thalidomide-NH-CH2-CONH-C2-PEG-bromine

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-NH-CH2-CONH-C2-PEG-bromine is a conjugate of the E3 ligase ligand and the linker, that can be used for synthesis of PROTAC degrader SK-3-91 (HY-137341) .
    Thalidomide-NH-CH2-CONH-C2-PEG-bromine

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