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SK-3-91

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137341
    SK-3-91

    		PROTACs Cancer
    SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases) . SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) TAE648 (HY-169396), the E3 ubiquitin ligase ligand (blue part) Thalidomide-NH-CH2-COOH (HY-131717) and the PROTAC linker (Bromo-PEG1-C2-azide) (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397).
    SK-3-91
  • HY-137340
    WH-10417-099

    		Ligands for E3 Ligase Others Cancer
    WH-10417-099 is a degrader that can simultaneously induce the degradation of the maximum number of unique kinases (over 125 unique kinases). WH-10417-099 can act as a PROTAC ubiquitin ligase and induce protein degradation through the E-STUB ubiquitinylation pathway.
    WH-10417-099
  • HY-169396
    TAE648

    		Ligands for Target Protein for PROTAC Cancer
    TAE648 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC SK-3-91 (HY-137341) .
    TAE648

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