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WH-10417-099 is a degrader that could collectively induce degradation of the largest number of unique kinases (>125 unique kinases).

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WH-10417-099 Chemical Structure

WH-10417-099 Chemical Structure

CAS No. : 2769753-42-4

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5 mg USD 460 In-stock
10 mg USD 740 In-stock
25 mg USD 1480 In-stock
50 mg USD 2550 In-stock
100 mg USD 4500 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

WH-10417-099 is a degrader that could collectively induce degradation of the largest number of unique kinases (>125 unique kinases)[1].

Molecular Weight

1039.16

Formula

C52H62N8O13S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCOCCC(NCCCN(C4CC4)S(C5=CC=C(C6=CN=C(N)C(C7=CC(CCNC8=O)=C8C=C7)=C6)C=C5)(=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (38.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9623 mL 4.8116 mL 9.6232 mL
5 mM 0.1925 mL 0.9623 mL 1.9246 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9623 mL 4.8116 mL 9.6232 mL 24.0579 mL
5 mM 0.1925 mL 0.9623 mL 1.9246 mL 4.8116 mL
10 mM 0.0962 mL 0.4812 mL 0.9623 mL 2.4058 mL
15 mM 0.0642 mL 0.3208 mL 0.6415 mL 1.6039 mL
20 mM 0.0481 mL 0.2406 mL 0.4812 mL 1.2029 mL
25 mM 0.0385 mL 0.1925 mL 0.3849 mL 0.9623 mL
30 mM 0.0321 mL 0.1604 mL 0.3208 mL 0.8019 mL
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WH-10417-099 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WH-10417-0992769753-42-4Othersunique kinasesMOLT-4 cellsSK-3-91DB0646SB1-G-187 cellsInhibitorinhibitorinhibit

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