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Salt active endonuclease

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-164927
    AV5124

    		Influenza Virus Infection Inflammation/Immunology
    AV5124, a prodrug of AV5116, is an orally active influenza virus cap-dependent endonuclease (CEN) endonuclease inhibitor .
    AV5124
  • HY-19357
    E3330
    3 Publications Verification

    APX-3330

    		 DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species Cardiovascular Disease Neurological Disease Cancer
    E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer activities .
    E3330
  • HY-123834
    FEN1-IN-1
    5 Publications Verification

    		 FLAP ATM/ATR Cancer
    FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg 2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers .
    FEN1-IN-1
  • HY-E70449
    Salt active endonuclease

    		Biochemical Assay Reagents Others
    Salt active endonuclease is a general, unspecific endonuclease that cleaves double-stranded and single-stranded DNA, and RNA. Salt active endonuclease can be used to remove DNA during protein expression and purification .
    Salt active endonuclease
  • HY-162242
    Cap-dependent endonuclease-IN-27

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-27 (Compound 8) is an orally active potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-27, an antiviral agent, shows activity against influenza B virus. Cap-dependent endonuclease-IN-27 has inhibitory activity against IFV A/WSN/33 (H1N1) polymerase (EC50 = 12.26 nM) .
    Cap-dependent endonuclease-IN-27
  • HY-158028
    PAN endonuclease-IN-2

    		Influenza Virus Infection
    PAN endonuclease-IN-2 (compound T-31) is a PAN endonuclease inhibitor (IC50: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication .
    PAN endonuclease-IN-2
  • HY-132894
    Pixavir marboxilo

    		Influenza Virus Infection
    Pixavir marboxilo is an orally active cap-dependent endonuclease inhibitor with high potency. Pixavir marboxilo can be used for the research of influenza .
    Pixavir marboxilo
  • HY-153570
    Influenza virus-IN-7

    		Influenza Virus Infection
    Influenza virus-IN-7 (Example 16) is an orally active cap-dependent endonuclease inhibitor that can be used for the research of influenza viral infectious diseases .
    Influenza virus-IN-7
  • HY-E70314
    Nuclease SM

    Non-specific endonuclease

    		 Endogenous Metabolite Others
    Nuclease SM is a non-specific endonuclease found mainly in Salmonella and is a basic protein. Nuclease SM is thermolabile and remains active for ~24 h at 25°C .
    Nuclease SM

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