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Results for "

Sir2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fungal (1) HDAC (1) Mitochondrial Metabolism (1) PARP (1) Sirtuin (3)
By Research Areas:	Cancer (4) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2031

Parishin	Others	Neurological Disease
Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of *Sir2/Uth1/TOR* signaling pathway .

HY-100585

Splitomicin Splitomycin	HDAC	Cancer
Splitomicin (Splitomycin) is a selective *Sir2p* inhibitor. Splitomicin inhibits NAD ⁺-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC₅₀ of 60 μM .

HY-15452

Selisistat 180+ Cited Publications EX-527	Sirtuin	Inflammation/Immunology Cancer
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC₅₀ of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease ^[2].

HY-N1926

Dihydrocoumarin Hydrocoumarin; Chroman-2-one	Sirtuin	Cancer
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and *SIRT2* with IC₅₀s of 208 μM and 295 μM, respectively .

HY-133859

M084	Mitochondrial Metabolism	Metabolic Disease
M084 is a benzimidazole derivative. M084 inhibits the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruites SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delays the aging process of C. elegans .

HY-N2031R

Parishin (Standard)	Others	Neurological Disease
Parishin (Standard) is the analytical standard of Parishin. This product is intended for research and analytical applications. Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway .

HY-W142410

2-Dodecanol	Fungal	Others
2-Dodecanol inhibits hyphal formation and *SIR2* expression in C. albicans .

HY-W156961

LS-75	PARP	Neurological Disease
LS-75 is a PARP-1 inhibitor with blood-brain permeability and IC₅₀ value of 18 μM. LS-75 has neuroprotective activity .

HY-N1926R

Dihydrocoumarin (Standard)	Sirtuin	Cancer
Dihydrocoumarin (Standard) is the analytical standard of Dihydrocoumarin. This product is intended for research and analytical applications. Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively .

Parishin	Other Terpenoids Structural Classification Gastrodia elata Bl. Terpenoids Orchidaceae Source classification Plants	Others
Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of *Sir2/Uth1/TOR* signaling pathway .

Dihydrocoumarin Hydrocoumarin; Chroman-2-one	Structural Classification other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Sirtuin
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and *SIRT2* with IC₅₀s of 208 μM and 295 μM, respectively .

Parishin (Standard)	Other Terpenoids Structural Classification Gastrodia elata Bl. Terpenoids Orchidaceae Source classification Plants	Others
Parishin (Standard) is the analytical standard of Parishin. This product is intended for research and analytical applications. Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway .

Dihydrocoumarin (Standard)	Structural Classification other families Source classification Coumarins Phenylpropanoids Plants	Sirtuin
Dihydrocoumarin (Standard) is the analytical standard of Dihydrocoumarin. This product is intended for research and analytical applications. Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively .

Species:	Human (9) Mouse (1)
Tag:	His (5) SUMO (1) Tag Free (1) Myc (1) GST (3) Flag (1)
Source:	E. coli (10)

Cat. No.	Compare	Product Name	Species	Source

HY-P71596

	SIRT1 Protein, Human (746a.a, His) 1 Publications Verification 75SirT1; hSir2; hSirT1; HST2; Sir2; Sir2 like 1; Sir2 like protein 1; Sir2, S.cerevisiae, homolog-like 1; Sir2-like protein 1; Sir2ALPHA; Sir2L1; Sirt1	Human	E. coli
	SIRT1 is an NAD-dependent protein deacetylase that integrates multiple cellular functions—cell cycle progression, DNA damage response, metabolism, apoptosis, and autophagy—by regulating the acetylation of various target proteins.SIRT1 responds to changes in the NAD(+)/NADH ratio caused by factors such as glucose deprivation, affecting chromatin remodeling through histone deacetylation, resulting in transcriptional regulation.SIRT1 Protein, Human (746a.a, His) is the recombinant human-derived SIRT1 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P701610

	SIRT3 Protein, Human (His, SUMO) SirT3; NAD-dependent protein deacetylase Sirtuin-3; mitochondrial; hSirT3; Regulatory protein Sir2 homolog 3; Sir2-like protein 3	Human	E. coli
	SIRT3 is an NAD-dependent protein deacetylase that dynamically affects the acetylation of mitochondrial target proteins, such as ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, and the ATP synthase subunit ATP5PO. Its deacetylation activity regulates cellular energy metabolism and fine-tunes tissue-specific ATP levels. SIRT3 Protein, Human (His, SUMO) is the recombinant human-derived SIRT3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of SIRT3 Protein, Human (His, SUMO) is 282 a.a., .

HY-P74545

	SIRT5 Protein, Human (Flag) NAD-dependent protein deacylase Sirtuin-5; Sir2-like protein 5; SirT5; Sir2L5	Human	E. coli
	SIRT5 Proteins, belonging to the sirtuin family, possess a sirtuin core domain and share homology with yeast Sir2 protein. They are classified in class III of the sirtuin family and undergo alternative splicing, resulting in multiple transcript variants. Their ubiquitous expression in tissues like the heart, liver, and 25 others suggests their involvement in diverse cellular processes. SIRT5 Protein, Human (Flag) is the recombinant human-derived SIRT5 protein, expressed by E. coli , with N-Flag labeled tag.

HY-P701609

	SIRT3 Protein, Human SirT3; NAD-dependent protein deacetylase Sirtuin-3; mitochondrial; hSirT3; Regulatory protein Sir2 homolog 3; Sir2-like protein 3	Human	E. coli
	SIRT3 is an NAD-dependent protein deacetylase that dynamically affects the acetylation of mitochondrial target proteins, such as ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, and the ATP synthase subunit ATP5PO. Its deacetylation activity regulates cellular energy metabolism and fine-tunes tissue-specific ATP levels. SIRT3 Protein, Human is the recombinant human-derived SIRT3 protein, expressed by E. coli , with tag free. The total length of SIRT3 Protein, Human is 282 a.a., .

HY-P702774

	SIRT3 Protein, Mouse (His, Myc) SirT3; NAD-dependent protein deacetylase Sirtuin-3; mitochondrial; hSirT3; Regulatory protein Sir2 homolog 3; Sir2-like protein 3	Mouse	E. coli
	SIRT3 Protein, Mouse (His, Myc) is the recombinant mouse-derived SIRT3, expressed by E. coli , with N-10*His, C-Myc labeled tag. ,

HY-P703015

	SIRT2 Protein, Human (GST) Sir2L; Sir2L2	Human	E. coli
	SIRT2 Protein, Human (GST) is the recombinant human-derived SIRT2, expressed by E. coli , with GST labeled tag. ,

HY-P702906

	SIRT2 Protein, Human (His) Sir2L; Sir2L2; Sirtuin 2	Human	E. coli
	SIRT2 Protein, Human (His) is the recombinant human-derived SIRT2, expressed by E. coli , with C-6*His labeled tag. ,

HY-P702952

	SIRT6 Protein, Human (GST) Sir2L6	Human	E. coli
	SIRT6 Protein, Human (GST) is the recombinant human-derived SIRT6, expressed by E. coli , with GST labeled tag. ,

HY-P703626

	Sirt6 Protein, Human (His) Sir2L6	Human	E. coli
	Sirt6 Protein, Human (His) is the recombinant human-derived Sirt6, expressed by E. coli , with His labeled tag. ,

HY-P702908

	SIRT4 Protein, Human (GST) Sir2L4; Sirtuin 4	Human	E. coli
	SIRT4 Protein, Human (GST) is the recombinant human-derived SIRT4, expressed by E. coli , with N-GST labeled tag. ,

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HY-P80319

	SIRT1 Antibody 1 Publications Verification SirT1; Sir2L1; NAD-dependent protein deacetylase Sirtuin-1; hSirT1; Regulatory protein Sir2 homolog 1; Sir2-like protein 1; hSir2; Sirtuin 1	WB, ICC/IF, IHC-P, IP	Human, Mouse
	SIRT1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 82 kDa, targeting to SIRT1. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse.

HY-P80892

	SIRT3 Antibody Sir2L3	WB, IHC-P	Human
	SIRT3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to SIRT3. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P81303

	Phospho-SIRT1 (Ser47) Antibody (YA1036) SirT1; Sir2L1; NAD-dependent protein deacetylase Sirtuin-1; hSirT1; Regulatory protein Sir2 homolog 1; Sir2-like protein 1; hSir2	WB, IHC-P, ICC/IF	Human
	Phospho-SIRT1 (Ser47) Antibody (YA1036) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1036), targeting Phospho-SIRT1 (Ser47), with a predicted molecular weight of 82 kDa (observed band size: 110 kDa). Phospho-SIRT1 (Ser47) Antibody (YA1036) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P81303A

	Phospho-SIRT1 (Thr530) Antibody (YA1037) SirT1; Sir2L1; NAD-dependent protein deacetylase Sirtuin-1; hSirT1; Regulatory protein Sir2 homolog 1; Sir2-like protein 1; hSir2	WB	Human
	Phospho-SIRT1 (Thr530) Antibody (YA1037) is a biotin-conjugated non-conjugated IgG antibody, targeting Phospho-SIRT1 (Thr530), with a predicted molecular weight of 82 kDa (observed band size: 120 kDa). Phospho-SIRT1 (Thr530) Antibody (YA1037) can be used for WB experiment in human background.

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Sir2

Inhibitors & Agonists

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Recombinant Proteins

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