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SirReal1-O-propargyl

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107453
    SirReal1-O-propargyl

    PROTAC Sirt2-binding moiety 1

    		 Ligands for Target Protein for PROTAC Cancer
    SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 [1]. SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    SirReal1-O-propargyl

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