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Results for "

Sterol biosynthesis

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

4

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126200
    Fenpropidin

    		Fungal Infection
    Fenpropidin is a sterol biosynthesis inhibitor fungicide .
    Fenpropidin
  • HY-114295A
    Geranyl diphosphate triammonium

    Geranyl pyrophosphate triammonium

    		 Endogenous Metabolite Metabolic Disease
    Geranyl diphosphate triammonium is a key intermediate in the isoprenoid biosynthesis pathway (IBP). Geranyl diphosphate triammonium plays key roles in cellular metabolism and is responsible for the production of both sterol and non-sterol isoprenoids .
    Geranyl diphosphate triammonium
  • HY-118065
    Fenhexamid

    KBR 2738

    		 Fungal Infection
    Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea) .
    Fenhexamid
  • HY-135761
    Penconazole
    1 Publications Verification

    		 Fungal Cholinesterase (ChE) Infection Neurological Disease
    Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats .
    Penconazole
  • HY-128033
    Fenpropimorph

    		Fungal Infection
    Fenpropimorph is a fungicide that inhibits the sterol pathway. Fenpropimorph inhibits δ8-δ7-sterol isomerase in yeast at low concentrations, with δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol. Fenpropimorph also inhibits sterol synthesis in certain plants and mammalian cells .
    Fenpropimorph
  • HY-126200R
    Fenpropidin (Standard)

    		Fungal Infection
    Fenpropidin (Standard) is the analytical standard of Fenpropidin. This product is intended for research and analytical applications. Fenpropidin is a sterol biosynthesis inhibitor fungicide .
    Fenpropidin (Standard)
  • HY-114295
    Geranyl diphosphate

    Geranyl pyrophosphate

    		 Endogenous Metabolite Metabolic Disease
    Geranyl diphosphate is a key intermediate in the isoprenoid biosynthesis pathway (IBP). HY-114295 plays key roles in cellular metabolism and is responsible for the production of both sterol and non-sterol isoprenoids .
    Geranyl diphosphate
  • HY-118065R
    Fenhexamid (Standard)

    		Fungal Infection
    Fenhexamid (Standard) is the analytical standard of Fenhexamid. This product is intended for research and analytical applications. Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea) .
    Fenhexamid (Standard)
  • HY-135761R
    Penconazole (Standard)

    		Fungal Cholinesterase (ChE) Infection Neurological Disease
    Penconazole (Standard) is the analytical standard of Penconazole. This product is intended for research and analytical applications. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats .
    Penconazole (Standard)
  • HY-B2097
    Incadronate disodium

    YM 175; Bisphonal

    		 Farnesyl Transferase Metabolic Disease
    Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (Ki=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC50=64 μM). Incadronate disodium has the potential for malignant tumors research .
    Incadronate disodium
  • HY-130702
    24(28)-Dehydroergosterol

    		Drug Derivative Others
    24(28)-Dehydroergosterol is a derivative of Episterol. Episterol is a sterol involved in the biosynthesis of steroids .
    24(28)-Dehydroergosterol
  • HY-128033R
    Fenpropimorph (Standard)

    		Fungal Infection
    Fenpropimorph (Standard) is the analytical standard of Fenpropimorph. This product is intended for research and analytical applications. Fenpropimorph is a fungicide that inhibits the sterol pathway. Fenpropimorph inhibits δ8-δ7-sterol isomerase in yeast at low concentrations, with δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol. Fenpropimorph also inhibits sterol synthesis in certain plants and mammalian cells .
    Fenpropimorph (Standard)
  • HY-E70515
    Human CYP51,High-Reductase

    		Cytochrome P450 Metabolic Disease
    Human CYP51, High-Reductase, a recombinant CYP51, is the cytochrome P450 enzymes required for biosynthesis of sterols in eukaryotes .
    Human CYP51,High-Reductase
  • HY-14282
    Lanoconazole

    		Fungal Infection Inflammation/Immunology
    Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi?in vitro?and?in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
    Lanoconazole
  • HY-149657
    SREBP/SCAP-IN-1

    		Fatty Acid Synthase (FASN) Metabolic Disease
    SREBP/SCAP-IN-1(compound 10b) is a selectiveSREBP/SCAPinhibitor .
    SREBP/SCAP-IN-1
  • HY-149658
    SREBP/SCAP-IN-2

    		Fatty Acid Synthase (FASN) Metabolic Disease
    SREBP/SCAP-IN-2(compound 13) is a selectiveSREBP/SCAPinhibitor .
    SREBP/SCAP-IN-2
  • HY-14282A
    (Z)-Lanoconazole

    		Fungal Infection Inflammation/Immunology
    (Z)-Lanoconazole is the Z configuration of Lanoconazole. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
    (Z)-Lanoconazole
  • HY-14282R
    Lanoconazole (Standard)

    		Fungal Infection Inflammation/Immunology
    Lanoconazole (Standard) is the analytical standard of Lanoconazole. This product is intended for research and analytical applications. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
    Lanoconazole (Standard)
  • HY-W749520
    Zymosterone

    		Dihydrofolate reductase (DHFR) Metabolic Disease
    Zymosterone is converted into zymosterol, an intermediate in cholesterol synthesis, through the action of the enzyme hydroxysteroid (17β) dehydrogenase 7 (HSD17B7), and this transformation, catalyzed by 3-keto sterol reductase (ERG27), plays a crucial role in the biosynthesis of ergosterol in yeast.
    Zymosterone
  • HY-B0846
    Dimethomorph

    		Fungal Androgen Receptor Parasite Infection
    Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 µM .
    Dimethomorph
  • HY-135761S
    Penconazole-d7

    		Fungal Cholinesterase (ChE) Infection
    Penconazole-d7 is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].
    Penconazole-d7
  • HY-130703
    5-Dehydroepisterol

    		Fungal Infection
    5-Dehydroepisterol is an episterol derivative and an intermediate in steroid biosynthesis. 5-Dehydroepisterol can be formed by C-5 sterol desaturase and converted into 24-methylenecholesterol by 7-dehydrocholesterol reductase. 5-Dehydroepisterol has anti-fungal activities .
    5-Dehydroepisterol
  • HY-N7255
    Cycloartenol

    		p38 MAPK Apoptosis Cancer
    Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .
    Cycloartenol
  • HY-B0846S
    Dimethomorph-d8

    		Fungal Androgen Receptor Parasite Infection
    Dimethomorph-d8 is the deuterium labeled Dimethomorph[1]. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 μM[2][3][4].
    Dimethomorph-d8
  • HY-B0846R
    Dimethomorph (Standard)

    		Fungal Androgen Receptor Parasite Infection
    Dimethomorph (Standard) is the analytical standard of Dimethomorph. This product is intended for research and analytical applications. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 µM .
    Dimethomorph (Standard)
  • HY-113725
    L 668411

    		HMG-CoA Reductase (HMGCR) Others
    L 668411 is a β-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.
    L 668411
  • HY-N7255R
    Cycloartenol (Standard)

    		p38 MAPK Apoptosis Cancer
    Cycloartenol (Standard) is the analytical standard of Cycloartenol. This product is intended for research and analytical applications. Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .
    Cycloartenol (Standard)
  • HY-107420
    AY 9944
    3 Publications Verification

    		 Endogenous Metabolite Metabolic Disease
    AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol .
    AY 9944
  • HY-118843
    Lombazole

    		Potassium Channel Infection
    Lombazole is an antimicrobial compound with activity that inhibits cell membrane synthesis. Lombazole had little effect on K+ permeability in S. aureus. Lombazole inhibited only de novo synthesis of cell enclosure in S. aureus, and this effect occurred before growth was affected. The main effect of lombazole was through inhibition of lipid synthesis. Lombazole may have an effect on key steps in lipid biosynthesis, as inferred from the lack of changes in lipid patterns after treatment. Lombazole also inhibited the sterol C-14 demethylation step in Candida albicans .
    Lombazole

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